The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease.
The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease.
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DOI：
10.1100/2012/792756
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发表时间：
2012
影响因子：
--
通讯作者：
Lin PT
中科院分区：
文献类型：
--
作者：
Lee BJ;Lin YC;Huang YC;Ko YW;Hsia S;Lin PT
较高的氧化应激可能导致冠状动脉疾病（CAD）的发病机制。本研究的目的是探讨辅酶 Q10 浓度与脂质过氧化、抗氧化酶活性以及 CAD 风险之间的关系。通过心导管检查确定一根主要冠状动脉至少有 50% 狭窄的患者被分配到病例组 (n = 51)。对照组（n = 102）由血液生化值正常的健康个体组成。测定血浆辅酶Q10、丙二醛（MDA）和抗氧化酶活性（过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx））。与对照组相比，患有 CAD 的受试者血浆辅酶 Q10、CAT 和 GPx 活性显着降低，MDA 和 SOD 水平显着升高。血浆辅酶Q10与CAT、GPx活性呈正相关，与MDA、SOD呈负相关。然而，在调整除 SOD 之外的 CAD 潜在混杂因素后，相关性并不显着。血浆辅酶 Q10 水平较高（≥0.52μmol/L）与降低 CAD 风险显着相关。我们的结果支持辅酶 Q10 的潜在心脏保护作用。
A higher oxidative stress may contribute to the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the relationship between coenzyme Q10 concentration and lipid peroxidation, antioxidant enzymes activities and the risk of CAD. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n = 51). The control group (n = 102) comprised healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, malondialdehyde (MDA) and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) were measured. Subjects with CAD had significant lower plasma coenzyme Q10, CAT and GPx activities and higher MDA and SOD levels compared to those of the control group. The plasma coenzyme Q10 was positively correlated with CAT and GPx activities and negatively correlated with MDA and SOD. However, the correlations were not significant after adjusting for the potential confounders of CAD with the exception of SOD. A higher level of plasma coenzyme Q10 (≥0.52 μmol/L) was significantly associated with reducing the risk of CAD. Our results support the potential cardioprotective impact of coenzyme Q10.
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