Impulsivity across the course of bipolar disorder.
Impulsivity across the course of bipolar disorder.
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DOI：
10.1111/j.1399-5618.2010.00806.x
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发表时间：
2010-05
影响因子：
5.4
通讯作者：
Arndt S
中科院分区：
文献类型：
--
作者：
Strakowski SM;Fleck DE;DelBello MP;Adler CM;Shear PK;Kotwal R;Arndt S
确定冲动控制异常是否在双相情感障碍的整个过程中持续存在，从而代表潜在的状态标记和内表型。通过三项旨在研究反应抑制、延迟满足能力和注意力的任务，对 108 名双相 I 型躁狂或混合型患者的冲动控制进行了测量；分别是停止信号任务、延迟奖励任务和连续性能任务。还获得了巴雷特冲动量表 (BIS-11) 分数。然后对患者进行长达一年的随访，如果他们出现抑郁或情绪正常，则用相同的措施重新评估。还使用相同的仪器两次对健康对照受试者进行评估，以评估测量稳定性。在基线时，与健康受试者相比，双相情感障碍受试者在所有三项任务上均表现出显着缺陷，这与双相躁狂/混合组中更冲动的反应一致。一般来说，当转为抑郁或发展为情绪正常时，这三种行为任务的表现就会正常化。相比之下，BIS-11 评分在躁狂期间升高，并且在双相情感障碍受试者出现抑郁或达到正常状态时保持升高状态。与健康受试者相比，I型双相情感障碍患者在狂躁时冲动的各个方面的实验室测试中表现出缺陷，这些缺陷随着康复和转变为抑郁症而基本恢复正常。然而，BIS 评分在整个疾病阶段持续升高。这些发现表明，冲动在双相情感障碍中既有情感状态依赖性又有特质成分。
To determine whether abnormalities of impulse control persist across the course of bipolar disorder, thereby representing potential state markers and endophenotypes. Impulse control of 108 bipolar I manic or mixed patients was measured on three tasks designed to study response inhibition, ability to delay gratification, and attention; namely a stop signal task, a delayed reward task, and a continuous performance task, respectively. Barrett Impulsivity Scale (BIS-11) scores were also obtained. Patients were then followed for up to one year and re-assessed with the same measures if they developed depression or euthymia. Healthy comparison subjects were also assessed with the same instruments on two occasions to assess measurement stability. At baseline, bipolar subjects demonstrated significant deficits on all three tasks as compared to healthy subjects, consistent with more impulsive responding in the bipolar manic/mixed group. In general, performance on the three behavioral tasks normalized upon switching to depression or developing euthymia. In contrast, BIS-11 scores were elevated during mania and remained elevated as bipolar subjects developed depression or achieved euthymia. Bipolar I disorder patients demonstrate deficits on laboratory tests of various aspects of impulsivity when manic, as compared to healthy subjects, that largely normalize with recovery and switching into depression. However, elevated BIS scores persist across phases of illness. These findings suggest that impulsivity has both affective-state dependent and trait components in bipolar disorder.
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影响因子：
7.3
作者：
McElroy, SL;Pope, HG;Strakowski, SM
通讯作者：
Strakowski, SM
影响因子：
6.6
作者：
Akiskal, Hagop S.;Kilzieh, Nael;Keller, Martin B.
通讯作者：
Keller, Martin B.
影响因子：
--
作者：
Judd, LL;Akiskal, HS;Keller, MB
通讯作者：
Keller, MB
影响因子：
8.2
作者：
Logan, GD;Schachar, RJ;Tannock, R
通讯作者：
Tannock, R
DOI：
10.1017/s1355617706061091
发表时间：
2006-11-01
影响因子：
2.6
作者：
Fuentes, Daniel;Tavares, Hermano;Gorenstein, Clarice
通讯作者：
Gorenstein, Clarice