Serum leptin levels, hormone levels, and hot flashes in midlife women.
Serum leptin levels, hormone levels, and hot flashes in midlife women.
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DOI：
10.1016/j.fertnstert.2009.04.001
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发表时间：
2010-08
影响因子：
6.7
通讯作者：
Zacur H
中科院分区：
文献类型：
--
作者：
Alexander C;Cochran CJ;Gallicchio L;Miller SR;Flaws JA;Zacur H
这项研究调查了正常体重和肥胖中年女性的血清瘦素水平、性类固醇激素水平和潮热之间的关系。横断面研究。大学诊所。211名年龄在45 - 54岁之间、身体质量指数(BMI) <25 kg/m2或≥30 kg/m2的非吸烟者高加索女性被纳入研究。干预：参与者完成一份调查问卷，并提供空腹血液样本，用于测量瘦素和性类固醇激素水平。采用相关和回归模型来检验瘦素水平、激素水平和潮热之间的关系。血清瘦素水平与BMI相关（r=0.75, p<0.0001）。瘦素水平与“是否经历过潮热”（p=0.04）、最近30天内的潮热（p=0.03）和潮热持续时间（>1年，p=0.03）有关。瘦素与睾酮、游离睾酮指数、游离雌激素指数呈正相关；同时，瘦素水平与性激素结合球蛋白（SHBG）水平呈负相关。在BMI≥30 kg/m2的女性中，瘦素水平不再与睾酮水平相关。基于这些数据，血清瘦素水平与中年女性潮热的发生和持续时间有关；然而，瘦素和血清雌二醇之间没有相关性。
This study examined the associations between serum leptin levels, sex steroid hormone levels, and hot flashes in normal weight and obese midlife women. Cross-sectional study. University clinic. Two-hundred and eleven Caucasian women who were non-smokers between the ages of 45 and 54 years with a body mass index (BMI) of <25 kg/m2 or ≥30 kg/m2 were included. Intervention(s): Participants completed a questionnaire and provided fasting blood samples, which were used to measure leptin and sex steroid hormone levels. Correlation and regression models were performed to examine associations between leptin levels, hormone levels, and hot flashes. Serum leptin levels Leptin levels were associated with BMI (r=0.75, p<0.0001). Leptin levels were associated with ‘ever experiencing hot flashes’ (p=0.04), hot flashes within the last 30 days, (p=0.03), and duration of hot flashes (>1 year, p=0.03). Leptin was positively correlated with testosterone, free testosterone index, and free estrogen index; meanwhile, leptin levels were inversely associated with levels of sex hormone binding globulin (SHBG). In women with a BMI≥30 kg/m2, leptin levels were no longer correlated with testosterone levels. Based on this data, serum leptin levels are associated with the occurrence and duration of hot flashes in midlife women; albeit, no correlation was found between leptin and serum estradiol.
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DOI：
10.1073/pnas.96.12.7047
发表时间：
1999-06-08
影响因子：
11.1
作者：
Luheshi, GN;Gardner, JD;Rothwell, NJ
通讯作者：
Rothwell, NJ
影响因子：
4.8
作者：
Meli, R;Pacilio, M;Di Carlo, R
通讯作者：
Di Carlo, R
DOI：
10.1089/152460901750067133
发表时间：
2001-01-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Freeman, EW;Sammel, MD;Hollander, L
通讯作者：
Hollander, L
DOI：
10.1111/j.1471-0528.1997.tb14352.x
发表时间：
1997-08-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
Kuh, DL;Wadsworth, M;Hardy, R
通讯作者：
Hardy, R
影响因子：
4.9
作者：
denTonkelaar, I;Seidell, JC;vanNoord, PAH
通讯作者：
vanNoord, PAH