ROS, Notch, and Wnt signaling pathways: crosstalk between three major regulators of cardiovascular biology.
ROS, Notch, and Wnt signaling pathways: crosstalk between three major regulators of cardiovascular biology.
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DOI：
10.1155/2014/318714
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发表时间：
2014
影响因子：
--
通讯作者：
Ferrari R
中科院分区：
文献类型：
--
作者：
Caliceti C;Nigro P;Rizzo P;Ferrari R
活性氧（ROS），传统上被认为是导致生物分子损伤的有毒副产物，现在被清楚地认识到是各种生物过程和病理状态的关键调节剂。心血管系统的发育和调节需要精心安排的活动；Notch和Wnt/β-catenin信号通路涉及心肌细胞和平滑肌细胞存活、血管生成、祖细胞募集和分化、动静脉规范、血管细胞迁移和心脏重构等许多方面。关于ROS在Notch和Wnt/β-catenin调节中的作用的一些新发现促使我们回顾它们在胚胎发生和出生后心血管系统中的新功能。
Reactive oxygen species (ROS), traditionally viewed as toxic by-products that cause damage to biomolecules, now are clearly recognized as key modulators in a variety of biological processes and pathological states. The development and regulation of the cardiovascular system require orchestrated activities; Notch and Wnt/β-catenin signaling pathways are implicated in many aspects of them, including cardiomyocytes and smooth muscle cells survival, angiogenesis, progenitor cells recruitment and differentiation, arteriovenous specification, vascular cell migration, and cardiac remodelling. Several novel findings regarding the role of ROS in Notch and Wnt/β-catenin modulation prompted us to review their emerging function in the cardiovascular system during embryogenesis and postnatally.
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影响因子：
4.6
作者：
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DOI：
10.1083/jcb.200806104
发表时间：
2008-10-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Campa VM;Gutiérrez-Lanza R;Cerignoli F;Díaz-Trelles R;Nelson B;Tsuji T;Barcova M;Jiang W;Mercola M
通讯作者：
Mercola M