The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.
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DOI：
10.1016/j.devcel.2010.05.006
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发表时间：
2010-06-15
影响因子：
11.8
通讯作者：
Dejana E
中科院分区：
文献类型：
--
作者：
Corada M;Nyqvist D;Orsenigo F;Caprini A;Giampietro C;Taketo MM;Iruela-Arispe ML;Adams RH;Dejana E
Wnt/β-Catenin途径是一个进化保守的信号系统，调节细胞分化和器官发生。我们发现Wnt/β-catenin信号的内皮特异性稳定改变了胚胎早期的血管发育。表型类似于Notch信号上调所引起的表型，包括缺乏血管重塑、体间血管延长改变、分支缺陷和静脉特性丧失。体内和体外数据表明，β-catenin上调DLL4转录，并强烈增加内皮细胞中的Notch信号，导致功能和形态的改变。β-连环蛋白信号的功能后果取决于血管发育的阶段，当在发育后期或出生后诱导功能获得突变时，该信号就会丢失。我们的发现建立了Wnt和Notch信号在血管发育中的联系。我们认为，早期和持续的β-连环蛋白信号阻止了正确的内皮细胞分化，改变了血管重构和动静脉规范。
The Wnt/β-catenin pathway is evolutionary conserved signaling system that regulates cell differentiation and organogenesis. We show that endothelial specific stabilization of Wnt/β-catenin signaling alters early vascular development in the embryo. The phenotype resembles that induced by upregulation of Notch signaling, including lack of vascular remodeling, altered elongation of the intersomitic vessels, defects in branching, and loss of venous identity. Both in vivo and in vitro data show that β-catenin upregulates Dll4 transcription and strongly increases Notch signaling in the endothelium, leading to functional and morphological alterations. The functional consequences of β-catenin signaling depend on the stage of vascular development and are lost when a gain-of-function mutation is induced at a late stage of development or postnatally. Our findings establish a link between Wnt and Notch signaling in vascular development. We propose that early and sustained β-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification.
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影响因子：
16
作者：
Gerety, SS;Wang, HU;Anderson, DJ
通讯作者：
Anderson, DJ
影响因子：
2.5
作者：
Alva, JA;Zovein, AC;Iruela-Arispe, ML
通讯作者：
Iruela-Arispe, ML
Wnt/β-catenin信号传导控制血脑屏障的发展。
影响因子：
7.8
作者：
Liebner, Stefan;Corada, Monica;Bangsow, Thorsten;Babbage, Jane;Taddei, Andrea;Czupalla, Cathrin J.;Reis, Marco;Felici, Angelina;Wolburg, Hartwig;Fruttiger, Marcus;Taketo, Makoto M.;von Melchner, Harald;Plate, Karl Heinz;Gerhardt, Holger;Dejana, Elisabetta
通讯作者：
Dejana, Elisabetta
影响因子：
7.8
作者：
Liebner, S;Cattelino, A;Dejana, E
通讯作者：
Dejana, E
影响因子：
64.5
作者：
Benedito, Rui;Roca, Cristina;Adams, Ralf H.
通讯作者：
Adams, Ralf H.