Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.
Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.
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DOI：
10.1038/s41467-021-23859-6
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发表时间：
2021-06-14
影响因子：
16.6
通讯作者：
Hasegawa K
中科院分区：
文献类型：
--
作者：
Raita Y;Pérez-Losada M;Freishtat RJ;Harmon B;Mansbach JM;Piedra PA;Zhu Z;Camargo CA;Hasegawa K
呼吸道合胞病毒（RSV）细支气管炎不仅是美国婴儿住院的主要原因，也是哮喘发展的主要危险因素。虽然新出现的证据表明RSV毛细支气管炎的临床异质性，但对其生物学上不同的内型知之甚少。在此，我们在一项多中心前瞻性队列研究中整合了221名因RSV毛细支气管炎住院的婴儿的临床、病毒、气道微生物组（物种水平）、转录组和代谢组数据。我们鉴定了四种具有生物学和临床意义的内型：B）临床局部微生物群。pneumoniae/M.卡他炎炎症IFN-高，C）临床严重微生物混合炎症IFN-低，和D）临床非特异性微生物组卡他炎炎症IL-6。特别地，与内型A婴儿相比，内型B婴儿-其特征在于高比例的IgE致敏和鼻病毒共感染，S. pneumoniae/M.卡他共显性、高IFN-α和-γ应答者发生哮喘的风险显著增高（9%对38%; OR，6.00：95%CI，2.08-21.9; P = 0.002）。我们的研究结果提供了一个证据基础，早期识别高危儿童在气道发育的关键时期。婴儿期呼吸道合胞病毒（RSV）毛细支气管炎是哮喘发生的主要危险因素。在这里，Raita等人将临床数据与气道微生物组、转录组和代谢组数据相结合，并确定了四种具有不同哮喘风险的内型。
Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little is known about its biologically-distinct endotypes. Here, we integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study. We identified four biologically- and clinically-meaningful endotypes: A) clinicalclassicmicrobiomeM. nonliquefaciensinflammationIFN-intermediate, B) clinicalatopicmicrobiomeS. pneumoniae/M. catarrhalisinflammationIFN-high, C) clinicalseveremicrobiomemixedinflammationIFN-low, and D) clinicalnon-atopicmicrobiomeM.catarrhalisinflammationIL-6. Particularly, compared with endotype A infants, endotype B infants—who are characterized by a high proportion of IgE sensitization and rhinovirus coinfection, S. pneumoniae/M. catarrhalis codominance, and high IFN-α and -γ response—had a significantly higher risk for developing asthma (9% vs. 38%; OR, 6.00: 95%CI, 2.08–21.9; P = 0.002). Our findings provide an evidence base for the early identification of high-risk children during a critical period of airway development. Respiratory syncytial virus (RSV) bronchiolitis during infancy is a major risk factor for asthma development. Here, Raita et al. integrate clinical data with airway microbiome, transcriptome, and metabolome data and identity four endotypes with differential risks for developing asthma.
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影响因子：
3
作者：
Byrd AL;Perez-Rogers JF;Manimaran S;Castro-Nallar E;Toma I;McCaffrey T;Siegel M;Benson G;Crandall KA;Johnson WE
通讯作者：
Johnson WE
呼吸道合胞病毒基因组载荷和疾病的严重程度患有细支气管炎的儿童：美国和芬兰的多中心队列研究。
DOI：
10.1093/infdis/jiu658
发表时间：
2015-05-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Hasegawa K;Jartti T;Mansbach JM;Laham FR;Jewell AM;Espinola JA;Piedra PA;Camargo CA Jr
通讯作者：
Camargo CA Jr
DOI：
10.1164/rccm.201405-0901pp
发表时间：
2015-01-01
影响因子：
24.7
作者：
Feldman, Amy S.;He, Yuan;Hartert, Tina V.
通讯作者：
Hartert, Tina V.
影响因子：
10
作者：
Dumas O;Mansbach JM;Jartti T;Hasegawa K;Sullivan AF;Piedra PA;Camargo CA Jr
通讯作者：
Camargo CA Jr
DOI：
10.1016/j.jaci.2018.08.043
发表时间：
2019-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Dumas O;Hasegawa K;Mansbach JM;Sullivan AF;Piedra PA;Camargo CA Jr
通讯作者：
Camargo CA Jr