Epidemiologic and molecular risk factors for contralateral breast cancer among young women.
Epidemiologic and molecular risk factors for contralateral breast cancer among young women.
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DOI：
10.1038/sj.bjc.6601042
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发表时间：
2003-08-04
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
在45岁之前被诊断出患有第一次乳腺癌的女性患第二次原发性对侧乳腺癌（CBC）的风险是普通人群中患第一次乳腺癌的女性的5.0倍以上。确定影响CBC风险的流行病学或分子因素可能有助于制定管理这些患者的新策略。在华盛顿的西雅图进行的两项病例对照研究中，共有1285名参与者在1983年至1992年被诊断为首次浸润性乳腺癌时年龄为21-44岁，随访至2001年12月。其中，77人被诊断为CBC和907肿瘤组织的第一个癌症进行了分析。体重指数（BMI）≤ 30 kg m−2的女性患CBC的风险是BMI ≤ 19.9 kg m−2的女性的2.6倍（95% CI：1.1-5.9）。第一个肿瘤c-erbB-2阳性的妇女有1.7倍（95%CI：1.0-3.0）的CBC风险。体重指数和c-erbB-2表达可能是年轻女性CBC的危险因素。需要进一步的观察性研究来证实这些发现，并评估在这一人群中检测c-erbB-2是否有助于识别CBC高危人群。
Women diagnosed with a first breast cancer before the age of 45 years have a greater than 5.0-fold risk of developing a second primary contralateral breast cancer (CBC) than women in the general population have of developing a first breast cancer. Identifying epidemiologic or molecular factors that influence CBC risk could aid in the development of new strategies for the management of these patients. A total of 1285 participants in two case–control studies conducted in Seattle, Washington, who were 21–44 years of age when diagnosed with a first invasive breast carcinoma from 1983 to 1992, were followed through December 2001. Of them, 77 were diagnosed with CBC and 907 tumour tissues from first cancers were analysed. Women with body mass indices (BMIs) ⩾30 kg m−2 had a 2.6-fold greater risk (95% CI: 1.1–5.9) of CBC compared to women with BMIs ⩽19.9 kg m−2. Women whose first tumour was c-erbB-2 positive had a 1.7-fold (95% CI: 1.0–3.0) excess CBC risk. Body mass index and c-erbB-2 expression may be risk factors for CBC in young women. Further observational studies are needed to confirm these findings and to evaluate whether testing for c-erbB-2 in this population may help identify those at high risk for CBC.
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影响因子：
8.4
作者：
HOLMBERG, L;LUND, E;MEIRIK, O
通讯作者：
MEIRIK, O
影响因子：
2.3
作者：
Volk, N;PompeKirn, V
通讯作者：
PompeKirn, V
绝经前乳腺癌的体型和生存。
影响因子：
8.8
作者：
Greenberg, E R;Vessey, M P;McPherson, K;Doll, R;Yeates, D
通讯作者：
Yeates, D
DOI：
10.1093/jnci/84.16.1245
发表时间：
1992-08-19
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
STORM, HH;ANDERSSON, M;PEDERSEN, M
通讯作者：
PEDERSEN, M
影响因子：
5
作者：
BERNSTEIN, JL;THOMPSON, WD;HOLFORD, TR
通讯作者：
HOLFORD, TR