Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis-Specific CD4+ T Cells in Blood and Airways During Latent M. tuberculosis Infection.
Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis-Specific CD4+ T Cells in Blood and Airways During Latent M. tuberculosis Infection.
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DOI：
10.1093/infdis/jix529
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发表时间：
2017-12-19
期刊：
影响因子：
--
通讯作者：
Burgers WA
中科院分区：
文献类型：
--
作者：
Bunjun R;Riou C;Soares AP;Thawer N;Müller TL;Kiravu A;Ginbot Z;Oni T;Goliath R;Kalsdorf B;von Groote-Bidlingmaier F;Hanekom W;Walzl G;Wilkinson RJ;Burgers WA
人类免疫缺陷病毒感染导致血液和肺部中结核分枝杆菌特异性CD4+T细胞的频率降低。然而，与未感染的人相比，T细胞流入肺部导致的特定CD4+T细胞的绝对数相似。人类免疫缺陷病毒1型(HIV)感染大大增加了患结核病的风险。在早期HIV感染期间，血液中结核分枝杆菌特异性的CD4+T细胞被广泛耗尽，但在这个阶段对肺部的反应知之甚少。鉴于粘膜器官是HIV介导的CD4+T细胞破坏的主要目标，我们研究了潜伏的结核分枝杆菌感染者和保留了CD4+T细胞计数的未经治疗的HIV混合感染患者的支气管肺泡灌洗液(BAL)中结核杆菌的特异性反应。结核分枝杆菌特异性CD_4~+T细胞细胞因子(干扰素γ、肿瘤坏死因子α和白介素2)反应的频率和功能在支气管肺泡灌洗液和血液中不一致。与非感染者相比，HIV感染者的BAL反应低15倍(P=.048)，而血液反应低2倍(P=.006)。然而，HIV感染者呼吸道中T细胞的增加导致BAL中结核分枝杆菌特异性CD4+T细胞的总数相似。我们的研究突出了在HIV感染期间研究结核分枝杆菌在疾病部位的免疫所获得的重要见解。
Human immunodeficiency virus infection leads to lower frequencies of CD4+ T cells specific for Mycobacterium tuberculosis in blood and lungs. However, an influx of T cells to the lungs results in similar absolute numbers of specific CD4+ T cells, compared with uninfected individuals. Human immunodeficiency virus type 1 (HIV) infection substantially increases the risk of developing tuberculosis. There is extensive depletion of Mycobacterium tuberculosis–specific CD4+ T cells in blood during early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4+ T-cell destruction, we investigated M. tuberculosis–specific responses in bronchoalveolar lavage (BAL) from persons with latent M. tuberculosis infection and untreated HIV coinfection with preserved CD4+ T-cell counts. M. tuberculosis–specific CD4+ T-cell cytokine (interferon γ, tumor necrosis factor α, and interleukin 2) responses were discordant in frequency and function between BAL and blood. Responses in BAL were 15-fold lower in HIV-infected persons as compared to uninfected persons (P = .048), whereas blood responses were 2-fold lower (P = .006). However, an increase in T cells in the airways in HIV-infected persons resulted in the overall number of M. tuberculosis–specific CD4+ T cells in BAL being similar. Our study highlights the important insights gained from studying M. tuberculosis immunity at the site of disease during HIV infection.
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影响因子：
4.8
作者：
Hokey, David A.;Wachholder, Robert;Sizemore, Donata
通讯作者：
Sizemore, Donata
DOI：
10.4049/jimmunol.1502094
发表时间：
2016-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Riou C;Strickland N;Soares AP;Corleis B;Kwon DS;Wherry EJ;Wilkinson RJ;Burgers WA
通讯作者：
Burgers WA
DOI：
10.1164/rccm.201405-0864oc
发表时间：
2014-10-15
影响因子：
24.7
作者：
Jambo, Kondwani C.;Banda, Dominic H.;Mwandumba, Henry C.
通讯作者：
Mwandumba, Henry C.
影响因子：
4.6
作者：
Hertoghe, T;Wajja, A;Vanham, G
通讯作者：
Vanham, G
DOI：
10.5588/ijtld.13.0032
发表时间：
2013-08-01
影响因子：
4
作者：
Gupta, R. K.;Lawn, S. D.;Wood, R.
通讯作者：
Wood, R.