Modulation of the M. tuberculosis cell envelope between replicating and non-replicating persistent bacteria.
Modulation of the M. tuberculosis cell envelope between replicating and non-replicating persistent bacteria.
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DOI：
10.1016/j.tube.2020.102007
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Purdy GE
中科院分区：
文献类型：
--
作者：
Stokas H;Rhodes HL;Purdy GE
结核分枝杆菌作为人类病原体的成功取决于细菌在氧气和营养不良的宿主环境中以静止形式持续存在的能力。体外研究已经证明，这些限制性环境诱导从细菌复制到非复制持久性（NRP）的转变。进入NRP涉及细菌代谢的变化和细胞包膜的重塑。在患者和动物模型样品中观察到与体外观察到的表型一致的结果。这篇评论的重点是复制和NRP M之间的细胞包膜差异。结核病和总结的方式，丝氨酸/苏氨酸蛋白激酶（STPKs）可能介导这一过程。
The success of Mycobacterium tuberculosis as a human pathogen depends on the bacterium’s ability to persist in a quiescent form in oxygen and nutrient-poor host environments. In vitro studies have demonstrated that these restricting environments induce a shift from bacterial replication to non-replicating persistence (NRP). Entry into NRP involves changes in bacterial metabolism and remodeling of the cell envelope. Findings consistent with the phenotypes observed in vitro have been observed in patient and animal model samples. This review focuses on the cell envelope differences seen between replicating and NRP M. tuberculosis and summarizes the ways in which serine/threonine protein kinases (STPKs) may mediate this process.
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影响因子：
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