Profile Screening of Differentially Expressed lncRNAs of Circulating Leukocytes in Type 2 Diabetes Patients and Differences From Type 1 Diabetes.
Profile Screening of Differentially Expressed lncRNAs of Circulating Leukocytes in Type 2 Diabetes Patients and Differences From Type 1 Diabetes.
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DOI：
10.3389/fendo.2021.690555
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发表时间：
2021
影响因子：
5.2
通讯作者：
Du X
中科院分区：
文献类型：
--
作者：
Lv J;Liu Y;Cui J;Fang H;Wu Y;Zhu X;Guo M;Li C;Dou J;Chen Z;Du X
Long noncoding RNAs (lncRNAs) have been reported to have multiple functions and can be used as markers of various diseases, including diabetes. This study was conducted to determine the lncRNA profile in leukocytes from patients with type 2 diabetes (T2D). Differential expression of lncRNAs in T2D and type 1 diabetes (T1D) was also examined. RNA sequencing was performed in a critically grouped sample of leukocytes from T2D patients and healthy persons. A total of 845 significantly differentially expressed lncRNAs were identified, with 260 downregulated and 585 upregulated lncRNAs in T2D. The analysis of functions of DE-lncRNA and constructed co-expression networks (CNC) showed that 21 lncRNAs and 117 mRNAs harbored more than 10 related genes in CNC. Fourteen of 21 lncRNAs were confirmed to be significantly differentially expressed was detected by qPCR between the T2D and control validation cohorts. We also identified a panel of 4 lncRNAs showing significant differences in expression between T1D and T2D. Collectively, hundreds of novel DE-lncRNAs we identified in leukocytes from T2D patients will aid in epigenetic mechanism studies. Fourteen confirmed DE-lncRNAs can be regarded as diagnostic markers or regulators of T2D, including 4 lncRNAs that chould distinguish T1D and T2D in clinical practice to avoid misdiagnosis.
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DOI：
10.1002/art.39520
发表时间：
2016-04
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Pearson MJ;Philp AM;Heward JA;Roux BT;Walsh DA;Davis ET;Lindsay MA;Jones SW
通讯作者：
Jones SW
DOI：
10.1161/atvbaha.114.303240
发表时间：
2014-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Bell RD;Long X;Lin M;Bergmann JH;Nanda V;Cowan SL;Zhou Q;Han Y;Spector DL;Zheng D;Miano JM
通讯作者：
Miano JM
影响因子：
8
作者：
Peng WX;Koirala P;Mo YY
通讯作者：
Mo YY
影响因子：
4.1
作者：
Damacharla, Divyasri;Thamilselvan, Vijayalakshmi;Kowluru, Anjaneyulu
通讯作者：
Kowluru, Anjaneyulu
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.