What does plasma CRP tell us about peripheral and central inflammation in depression?
What does plasma CRP tell us about peripheral and central inflammation in depression?
复制标题
DOI：
10.1038/s41380-018-0096-3
复制
发表时间：
2020-06
影响因子：
11
通讯作者：
Miller AH
中科院分区：
文献类型：
--
作者：
Felger JC;Haroon E;Patel TA;Goldsmith DR;Wommack EC;Woolwine BJ;Le NA;Feinberg R;Tansey MG;Miller AH
外周血c反应蛋白（CRP）是临床上用于测量全身炎症的生物标志物，在重度抑郁症（MDD）患者中可重复增加。此外，MDD患者外周血CRP升高与奖赏回路改变和与快感缺乏症状相关的脑谷氨酸增加有关。然而，外周CRP与抑郁症患者其他外周和中枢炎症标志物之间的关系尚未确定。血浆（n=89）和脑脊液（n=73）采集自医学稳定、目前未用药的成年MDD门诊患者。检测血浆和脑脊液CRP、血浆和脑脊液炎症因子（白细胞介素[IL]-6、肿瘤坏死因子[TNF]和IL-1 β）及其可溶性受体/拮抗剂的相关性。血浆和脑脊液炎症标志物与抑郁症状（包括快感缺乏和动机降低（RM））之间的关系也进行了探讨。血浆CRP与多种血浆炎症标志物相关（均p<0.05），血浆CRP与CSF CRP相关性强（r=0.855, p<0.001）。CSF CRP反过来与CSF细胞因子受体/拮抗剂相关（均p<0.05）。主成分分析显示，脑脊液炎症标志物簇与高血浆CRP （bbb3mg /L）相关，并与抑郁症状严重程度相关。这些发现是由CSF TNF驱动的，它与RM （r=0.236, p=0.045）和CSF IL-6可溶性受体（r=0.301, p=0.010）相关，在整个样本中，特别是女性中。CRP似乎是一种反映外周和中枢炎症的外周生物标志物，似乎非常适合指导MDD患者靶向TNF和IL-6的免疫治疗。
Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a subset of patients with major depressive disorder (MDD). Furthermore, increased peripheral blood CRP in MDD has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. Nevertheless, the relationship between peripheral CRP and other peripheral and central markers of inflammation in depressed patients has not been established. Plasma (n=89) and CSF (n=73) was collected from medically-stable, currently-unmedicated adult outpatients with MDD. Associations among plasma and CSF CRP and plasma and CSF inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF] and IL-1beta) and their soluble receptors/antagonists were examined. Relationships between plasma and CSF inflammatory markers and depressive symptoms including anhedonia and reduced motivation (RM) were also explored. Plasma CRP was correlated with multiple plasma inflammatory markers (all p<0.05), and a strong correlation was found between plasma and CSF CRP (r=0.855, p<0.001). CSF CRP in turn correlated with CSF cytokine receptors/antagonists (all p<0.05). Principal component analyses revealed clusters of CSF inflammatory markers that were associated with high plasma CRP (>3mg/L) and correlated with depressive symptom severity. These findings were driven by CSF TNF, which correlated with RM (r=0.236, p=0.045), and CSF IL-6 soluble receptor, which correlated with anhedonia (r=0.301, p=0.010) in the sample as a whole and particularly females. CRP appears to be a peripheral biomarker that reflects peripheral and central inflammation and seems well-suited for guiding immunotherapies targeting TNF and IL-6 in patients with MDD.
登录
查看更多内容
DOI：
10.1016/j.bbi.2015.06.001
发表时间：
2015-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Haapakoski R;Mathieu J;Ebmeier KP;Alenius H;Kivimäki M
通讯作者：
Kivimäki M
影响因子：
3.5
作者：
Algotsson, A.;Winblad, B.
通讯作者：
Winblad, B.
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
--
作者：
Capuron L;Pagnoni G;Drake DF;Woolwine BJ;Spivey JR;Crowe RJ;Votaw JR;Goodman MM;Miller AH
通讯作者：
Miller AH
影响因子：
11
作者：
Felger JC;Li Z;Haroon E;Woolwine BJ;Jung MY;Hu X;Miller AH
通讯作者：
Miller AH