Studies of Tumor Suppressor Genes via Chromosome Engineering.
Studies of Tumor Suppressor Genes via Chromosome Engineering.
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DOI：
10.3390/cancers8010004
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发表时间：
2015-12-30
期刊：
影响因子：
5.2
通讯作者：
Oshimura M
中科院分区：
文献类型：
--
作者：
Kugoh H;Ohira T;Oshimura M
恶性肿瘤的发展和进展可能是由于遗传改变的连续积累，包括功能失调的肿瘤抑制基因。然而，肿瘤发生的信号机制尚未完全阐明。新的肿瘤相关基因的发现对我们理解恶性肿瘤的发生和发展起着至关重要的作用。基于微细胞介导的染色体转移（MMCT）的染色体工程技术是筛选抑癌基因的有效途径。这些研究揭示了至少五种肿瘤抑制作用。新的肿瘤抑制基因的发现提供了对恶性肿瘤发生和发展的复杂信号通路的更好理解。这些进展正被用于开发针对癌症的靶向药物和新的生物疗法。
The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer.
DOI：
10.1111/j.1349-7006.1989.tb02278.x
发表时间：
1989-03
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Koi M;Morita H;Shimizu M;Oshimura M
通讯作者：
Oshimura M