Gene regulation by growth hormone.
Gene regulation by growth hormone.
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DOI：
10.1007/s00467-009-1258-y
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发表时间：
2010-04
影响因子：
3
通讯作者：
Chia, Dennis J.
中科院分区：
文献类型：
--
作者：
Rotwein, Peter;Chia, Dennis J.
自从生长激素（GH）作用的生长调节素假说在50多年前首次提出以来，GH和胰岛素样生长因子-I（IGF-I）在人类生长中的关键作用已经扩展到包括对组织维护和修复的重要作用。最近的观察表明，这种途径有负面影响，因为它被认为是几种人类癌症发展的潜在因素，并与实验动物寿命缩短有关。这篇简短的评论重点关注GH基因调节的基本方面，因为长期的激素效应都需要基因表达的变化。将讨论的主题包括GH刺激的信号转导途径，GH的基因激活和基因抑制的机制，并通过GH刺激的转录因子，信号转导和转录激活因子（Stat）5 b控制IGF-I基因转录的分析。
Since the somatomedin hypothesis of growth hormone (GH) action was first formulated more than 50 years ago, the key roles of both GH and insulin-like growth factor-I (IGF-I) in human growth have been extended to include important effects on tissue maintenance and repair. More recent observations have revealed that this pathway has a negative side, as it has been implicated as a potential contributor to the development of several human cancers and has been linked to diminished lifespan in experimental animals. This brief review focuses on fundamental aspects of gene regulation by GH, as long-term hormonal effects all require changes in gene expression. Topics to be discussed include GH-stimulated signal transduction pathways, mechanisms of gene activation and gene repression by GH, and an analysis of control of IGF-I gene transcription by the GH-stimulated transcription factor, signal transducer and activator of transcription (Stat)5b.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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作者：
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通讯作者：
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