A sticky situation: When trypanosomatids attach to insect tissues.
A sticky situation: When trypanosomatids attach to insect tissues.
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DOI：
10.1371/journal.ppat.1011854
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发表时间：
2023-12
期刊：
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
锥虫向其哺乳动物宿主的传播需要其昆虫载体中的一系列复杂的发育转变，包括稳定地附着于昆虫组织。虽然对附着细胞有许多超微结构描述，但我们对该过程中涉及的信号事件和分子机制知之甚少。每种锥虫在其生命周期的特定阶段附着在昆虫的特定组织上。附着是由鞭毛介导的，鞭毛被修饰以在鞭毛膜的扩展区域内容纳富含毒素的噬斑。附着在分化为哺乳动物感染阶段之前，在某些情况下，已经证明了直接的机械联系。本文综述了锥虫在昆虫体内附着的结构、功能、信号转导、候选分子和基因表达变化等方面的研究进展。我们还强调了关于这一进程的剩余问题，以及该领域如何准备通过现代方法解决这些问题。
Transmission of trypanosomatids to their mammalian hosts requires a complex series of developmental transitions in their insect vectors, including stable attachment to an insect tissue. While there are many ultrastructural descriptions of attached cells, we know little about the signaling events and molecular mechanisms involved in this process. Each trypanosomatid species attaches to a specific tissue in the insect at a particular stage of its life cycle. Attachment is mediated by the flagellum, which is modified to accommodate a filament-rich plaque within an expanded region of the flagellar membrane. Attachment immediately precedes differentiation to the mammal-infectious stage and in some cases a direct mechanistic link has been demonstrated. In this review, we summarize the current state of knowledge of trypanosomatid attachment in insects, including structure, function, signaling, candidate molecules, and changes in gene expression. We also highlight remaining questions about this process and how the field is poised to address them through modern approaches.
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影响因子：
28.3
作者：
通讯作者：
--
影响因子：
3.8
作者：
Savage AF;Cerqueira GC;Regmi S;Wu Y;El Sayed NM;Aksoy S
通讯作者：
Aksoy S
DOI：
10.1007/bf00335467
发表时间：
1970-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
BROOKER, BE
通讯作者：
BROOKER, BE
影响因子：
7.8
作者：
BONALDO, MC;SOUTOPADRON, T;GOLDENBERG, S
通讯作者：
GOLDENBERG, S
影响因子：
4
作者：
Bates PA
通讯作者：
Bates PA