Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction.
Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction.
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DOI：
10.1111/j.1474-9726.2011.00764.x
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发表时间：
2012-02
期刊：
影响因子：
7.8
通讯作者：
Shin T
中科院分区：
文献类型：
--
作者：
Tomihara K;Shin T;Hurez VJ;Yagita H;Pardoll DM;Zhang B;Curiel TJ;Shin T
由于大多数癌症患者都是老年人，并且由于免疫功能在衰老过程中发生了变化，因此在设计新的癌症免疫疗法时考虑衰老相关的免疫学变化非常重要。因此，我们比较了年轻小鼠和老年小鼠的免疫群体，发现B7-DC+（PD-L2/CD 273）B细胞（年轻小鼠中的少数群体）在老年小鼠中显著增加。老年小鼠的B7-DC+ B细胞可显著增强Th 1和Th 17细胞的诱导作用，而这种作用在体内外均可被抗B7-DC抗体阻断。此外，在老年小鼠中肿瘤生长的阻滞在很大程度上是B7-DC依赖的。用来自老年小鼠的B7-DC+ B细胞免疫，由于增加了肿瘤抗原特异性细胞毒性T淋巴细胞的诱导，在年轻小鼠中的肿瘤生长被显著抑制。这些数据表明，B7-DC+ B细胞可以在衰老相关的癌症免疫病理学以及其他衰老相关疾病中发挥重要作用，并进一步表明B7-DC+ B细胞具有未来癌症免疫治疗的潜力。
Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for aging-associated immunological alterations in the design of new cancer immunotherapies. We thus compared immune populations in young and aged mice and found that B7-DC+ (PD-L2/CD273) B cells, a minor population in young mice, were significantly increased in aged mice. Induction of both Th1 and Th17 cells was significantly augmented by B7-DC+ B cells from aged mice, and this effect was blocked with anti-B7-DC antibodies in vitro and in vivo. Moreover, retardation of tumor growth in aged mice was largely B7-DC dependent. Tumor growth in young mice was significantly inhibited by immunization with B7-DC+ B cells from aged mice owing to increased induction of tumor antigen-specific cytotoxic T lymphocytes. These data indicate that B7-DC+ B cells could play an important role in aging-associated cancer immunopathology as well as in other aging-associated diseases and further suggest that B7-DC+ B cells have potential for future cancer immunotherapy.
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影响因子：
32.4
作者：
Nurieva, Roza I.;Chung, Yeonseok;Hwang, Daehee;Yang, Xuexian O.;Kang, Hong Soon;Ma, Li;Wang, Yi-Hong;Watowich, Stephanie S.;Jetten, Anton M.;Tian, Qiang;Dong, Chen
通讯作者：
Dong, Chen
影响因子：
30.5
作者：
Latchman, Y;Wood, CR;Freeman, GJ
通讯作者：
Freeman, GJ
DOI：
10.1016/j.bbrc.2007.10.156
发表时间：
2008-01-04
影响因子：
3.1
作者：
Matsumoto, Koichiro;Fukuyama, Satoru;Inoue, Hiromasa
通讯作者：
Inoue, Hiromasa
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John
影响因子：
5.8
作者：
Lustgarten, Joseph
通讯作者：
Lustgarten, Joseph