Multi-organ comparison of flow-based arterial spin labeling techniques: Spatially non-selective labeling for cerebral and renal perfusion imaging.
Multi-organ comparison of flow-based arterial spin labeling techniques: Spatially non-selective labeling for cerebral and renal perfusion imaging.
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DOI：
10.1002/mrm.28603
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发表时间：
2021-05
影响因子：
3.3
通讯作者：
Schmid S
中科院分区：
文献类型：
--
作者：
Franklin SL;Bones IK;Harteveld AA;Hirschler L;van Stralen M;Qin Q;de Boer A;Hoogduin JM;Bos C;van Osch MJP;Schmid S
基于血流的动脉自旋标记(ASL)技术为更传统的空间选择性ASL技术提供了一种对通过时间不敏感的替代技术。然而，目前还不清楚哪种基于血流的ASL技术表现最好，也不清楚这些技术在脑外的表现如何(例如，考虑到流动动力学、场不均匀和器官运动)。在本研究中，我们旨在将4种基于血流的ASL技术(即速度选择性ASL、加速度选择性ASL、多速度选择性饱和ASL和制备ASL的速度选择性反转[VSI-ASL])与目前脑(即伪连续ASL[pCASL])和肾脏(即pCASL和流动交替反转恢复[FIRE])的空间选择性参考技术进行比较。健康受试者在3T时分别进行5次脑扫描和6次肾脏扫描。根据时间信噪比(TSNR)、对使用视觉刺激(大脑)的灌注变化的敏感性以及对呼吸运动的稳健性(通过比较在起搏呼吸和自由呼吸(肾脏)中获得的扫描)，生成灌注加权信号(PWS)图，并比较ASL技术。在脑内，所有基于血流的ASL技术显示的tSNR与pCASL相似，但只有VSI-ASL对血流变化的敏感性相似。在肾脏，所有基于血流的ASL技术都有类似的tSNR，尽管都低于FAIR。此外，VSI-ASL对B1不均一性表现出敏感性。所有的ASL技术对呼吸运动都是相对健壮的。在大脑和肾脏中，基于流量的ASL技术提供了一种空间选择性ASL技术的替代方案，无需规划且对传输时间不敏感。VSI-ASL在整体上表现出最大的潜力，在大脑中表现出与黄金标准pCASL相似的表现。然而，在肾脏，降低VSI-ASL的B1敏感性是必要的，以匹配公平的表现。
Flow‐based arterial spin labeling (ASL) techniques provide a transit‐time insensitive alternative to the more conventional spatially selective ASL techniques. However, it is not clear which flow‐based ASL technique performs best and also, how these techniques perform outside the brain (taking into account eg, flow‐dynamics, field‐inhomogeneity, and organ motion). In the current study we aimed to compare 4 flow‐based ASL techniques (ie, velocity selective ASL, acceleration selective ASL, multiple velocity selective saturation ASL, and velocity selective inversion prepared ASL [VSI‐ASL]) to the current spatially selective reference techniques in brain (ie, pseudo‐continuous ASL [pCASL]) and kidney (ie, pCASL and flow alternating inversion recovery [FAIR]). Brain (n = 5) and kidney (n = 6) scans were performed in healthy subjects at 3T. Perfusion‐weighted signal (PWS) maps were generated and ASL techniques were compared based on temporal SNR (tSNR), sensitivity to perfusion changes using a visual stimulus (brain) and robustness to respiratory motion by comparing scans acquired in paced‐breathing and free‐breathing (kidney). In brain, all flow‐based ASL techniques showed similar tSNR as pCASL, but only VSI‐ASL showed similar sensitivity to perfusion changes. In kidney, all flow‐based ASL techniques had comparable tSNR, although all lower than FAIR. In addition, VSI‐ASL showed a sensitivity to B1‐inhomogeneity. All ASL techniques were relatively robust to respiratory motion. In both brain and kidney, flow‐based ASL techniques provide a planning‐free and transit‐time insensitive alternative to spatially selective ASL techniques. VSI‐ASL shows the most potential overall, showing similar performance as the golden standard pCASL in brain. However, in kidney, a reduction of B1‐sensitivity of VSI‐ASL is necessary to match the performance of FAIR.
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影响因子：
3.3
作者：
Guo, Jia;Wong, Eric C.
通讯作者：
Wong, Eric C.
影响因子：
0.6
作者：
Ritter, Felix;Boskamp, Tobias;Peitgen, Heinz-Otto
通讯作者：
Peitgen, Heinz-Otto
影响因子：
3.3
作者：
Meakin, James A.;Jezzard, Peter
通讯作者：
Jezzard, Peter
影响因子：
3.3
作者：
Franklin, Suzanne L.;Schmid, Sophie;van Osch, Matthias J. P.
通讯作者：
van Osch, Matthias J. P.
DOI：
10.1016/b978-012372560-8/50041-3
发表时间：
2007-01-01
期刊：
STATISTICAL PARAMETRIC MAPPING: THE ANALYSIS OF FUNCTIONAL BRAIN IMAGES
影响因子：
--
作者：
Friston, K.
通讯作者：
Friston, K.