Female gonadal hormones differentially modulate cocaine-induced behavioral sensitization in Fischer, Lewis, and Sprague-Dawley rats.
Female gonadal hormones differentially modulate cocaine-induced behavioral sensitization in Fischer, Lewis, and Sprague-Dawley rats.
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雌性性腺激素差异调节费舍尔、刘易斯和斯普拉格-道利大鼠中可卡因诱导的行为敏化。
DOI：
--
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发表时间：
1999
影响因子：
3.5
通讯作者：
David H. Kim
中科院分区：
文献类型：
--
作者：
Ratna Sircar;David H. Kim
有证据表明，雄性大鼠可卡因致敏性存在遗传差异。本研究旨在研究遗传上不同的近交系（Fischer 344和刘易斯）和远交系（Sprague-Dawley）雌性大鼠的可卡因致敏性。将所有雌性大鼠双侧卵巢切除，并随机分为四个实验组之一：1）苯甲酸雌二醇组，2）孕酮组，3）苯甲酸雌二醇+孕酮组，4）卵巢切除组。其他对照包括假手术雌性大鼠、接受单次油注射的雌性大鼠和接受重复油注射的雌性大鼠。为了确定可卡因的急性和慢性效应中与性别有关的差异，将从雌性大鼠获得的数据与从应变和体重匹配的雄性大鼠获得的数据进行了比较。苯甲酸雌二醇加孕酮雌性大鼠表现出更大的运动效应，在响应急性剂量的可卡因，并有更强大的敏感性，在响应重复可卡因比雄性大鼠。双侧卵巢切除消除可卡因致敏。在所有研究的大鼠品系中，单独使用孕酮并不能改变卵巢切除术诱导的可卡因行为衰减，但单独使用雌激素可以恢复可卡因诱导的行为敏化。有显着的应变效应的程度性腺垂体诱导的调制可卡因致敏的雌性大鼠。雌性刘易斯大鼠对重复可卡因效应极其敏感，而Fischer 344雌性大鼠仅显示出边际效应。Sprague-Dawley大鼠在行为敏感性方面处于中等水平。本研究强烈支持的假设，雌性大鼠更敏感的急性和慢性可卡因的行为影响比雄性大鼠和应变依赖的影响。这也表明雌激素在雌性大鼠对可卡因致敏的敏感性增加中起重要作用。总之，这些数据表明可卡因诱导的行为效应中卵巢类固醇激素和遗传因素之间存在显著的相互作用。
Evidence suggests the existence of genetic differences in cocaine sensitization in male rats. The present study was undertaken to investigate cocaine sensitization in female rats of genetically distinct inbred (Fischer 344 and Lewis) and outbred (Sprague-Dawley) strains. All female rats were bilaterally ovariectomized and randomly assigned to one of four experimental groups: 1) estradiol benzoate group, 2) progesterone group, 3) estradiol benzoate-plus-progesterone group, and 4) ovariectomized group. Additional controls included sham-operated female rats, female rats that received a single oil injection, and female rats that received repeated oil injections. To determine gender-related differences in the acute and chronic effects of cocaine, data obtained from female rats were compared with those from strain- and weight-matched male rats. Estradiol benzoate-plus-progesterone female rats showed greater locomotor effect in response to an acute dose of cocaine and had more robust sensitization in response to repeated cocaine than did male rats. The bilateral removal of ovaries abolished cocaine sensitization. In all strains of rats studied, progesterone alone did not alter the ovariectomy-induced attenuation of cocaine behavior, but estrogen alone restored cocaine-induced behavioral sensitization. There were significant strain effects on the degree of gonadal hormonal-induced modulation of cocaine sensitization in female rats. Female Lewis rats were extremely sensitive to repeated-cocaine effects, whereas the Fischer 344 female rats showed only marginal effects. The Sprague-Dawley rats ranked intermediate in their behavioral sensitivity. The present study strongly supports the hypothesis that female rats are more sensitive to both acute and chronic behavioral effects of cocaine than are male rats and that the effects are strain dependent. It also shows that estrogen plays an important role in the increased sensitivity of female rats to cocaine sensitization. Together, these data indicate significant interactions between ovarian steroid hormones and genetic factors in cocaine-induced behavioral effects.
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大麻、情感和耐受性：女性亚慢性自我管理的研究。
DOI：
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发表时间：
1984
期刊：
NIDA research monograph
影响因子：
--
作者：
Babor,TF;Lex,BW;Mendelson,JH;Mello,NK
通讯作者：
Mello,NK
DOI：
--
发表时间：
1993-10
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
P. Kalivas;J. E. Alesdatter
通讯作者：
P. Kalivas;J. E. Alesdatter
Fischer 和 Lewis 大鼠品系在条件性位置偏爱和行为敏化方面表现出不同的可卡因效应，但在运动活动或条件性味觉厌恶方面没有表现出差异。
DOI：
--
发表时间：
1994
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Kosten,TA;Miserendino,MJ;Chi,S;Nestler,EJ
通讯作者：
Nestler,EJ
Long-Evans 大鼠中的可卡因 LD50 不会因怀孕或孕激素而改变。
影响因子：
2.9
作者：
Glantz,JC;WoodsJr,JR
通讯作者：
WoodsJr,JR
对可卡因引起的轮换敏感性的性别差异。
影响因子：
5
作者：
Glick,SD;Hinds,PA
通讯作者：
Hinds,PA