Could B7-H4 serve as a target to activate anti-cancer immunity?
Could B7-H4 serve as a target to activate anti-cancer immunity?
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B7-H4能否作为激活抗癌免疫的靶点？
DOI：
10.1016/j.intimp.2016.05.020
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发表时间：
2016-09
影响因子：
5.6
通讯作者：
Che Fengyuan
中科院分区：
文献类型：
--
作者：
Wang Lijuan;Heng Xueyuan;Lu Yong;Cai Zhen;Yi Qing;Che Fengyuan
It has been over 13 years since the identification of B7-H4, the co-stimulatory molecule of B7 family members. While B7-H4 mRNA is widely distributed protein expression seems to be limited on tissues. Various cytokines and inflammatory mediators induce the expression of B7-H4. However, the specific regulatory mechanisms of B7-H4 remain to be defined. Recently, it has been shown that B7-H4 executes an inhibitory function in the T-cell response via reduced expansion, cell cycle arrest, decreased cytokine secretion and induced apoptosis of activated T-cells. Furthermore, B7-H4 suppresses the function of antigen presenting cells (APCs) and promotes the proliferation and development of regulatory T-cells (Treg). Moreover, a growing body of literature demonstrates that various cancers express B7-H4 and that the expression levels of B7-H4 correlate with cancer size, histological type, pathologic stage, grade, infiltration, lymph node metastasis, cancer progression, recurrence and death. The over-expression of B7-H4 in cancer may be related to an increased resistance to immune responses. The aim of this review is to supply an overview of the advances in the regulation and function of B7-H4. Additionally, many studies have suggested that B7-H4 is a molecular target for therapeutic intervention in cancer and that targeting B7-H4 may have promising potential for improving the efficacy of immunotherapy for cancer patients.
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影响因子：
4.2
作者：
Qian Y;Shen L;Xu C;Wu Z;Brockmeyer NH;Altmeyer P;Wu N;Yao HP
通讯作者：
Yao HP
影响因子：
4.7
作者：
Tringler, B;Liu, WH;Shroyer, KR
通讯作者：
Shroyer, KR
影响因子：
--
作者：
Lili Zhang;S. Shao;Yan Wu
通讯作者：
Lili Zhang;S. Shao;Yan Wu
影响因子：
4.7
作者：
Mockler MB;Conroy MJ;Lysaght J
通讯作者：
Lysaght J
肿瘤微环境中的 B7x 和骨髓源性抑制细胞：两个城市的故事。
影响因子：
7.2
作者：
Jeon H;Ohaegbulam KC;Abadi YM;Zang X
通讯作者：
Zang X