Emerging role of nanog in tumorigenesis and cancer stem cells.
Emerging role of nanog in tumorigenesis and cancer stem cells.
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DOI：
10.1002/ijc.28690
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发表时间：
2014-12-15
影响因子：
6.4
通讯作者：
Pan, Quintin
中科院分区：
文献类型：
--
作者：
Santaliz-Ruiz, Luis E. I. V.;Xie, Xiujie;Old, Matthew;Teknos, Theodoros N.;Pan, Quintin
关键词：
Nanog是一种转录因子，已被公认为胚胎干细胞（ESC）维持的关键调节因子。最近的证据表明，Nanog是失调的，并密切参与促进肿瘤发生，部分通过调节癌症干细胞（CSC）的人口。Nanog升高与许多上皮恶性肿瘤的预后较差相关。Nanog富含CSC，Nanog的消融足以减少CSC池。Nanog还被认为促进了化疗耐药性和上皮-间质转化（EMT）。对Nanog信号级联、上游调节因子和下游效应因子的深入了解开始出现，但仍有待充分阐明。本文综述了Nanog在肿瘤发生和CSC中的新作用。
Nanog is a transcription factor that is well-established as a key regulator of embryonic stem cell (ESC) maintenance. Recent evidence demonstrates that Nanog is dysregulated and intimately involved in promoting tumorigenesis in part through regulation of the cancer stem cell (CSC) population. Elevated Nanog is associated with poorer outcome in numerous epithelial malignancies. Nanog is enriched in CSCs and ablation of Nanog is sufficient to reduce the CSC pool. Nanog has also been implicated to promote chemoresistance and epithelial-mesenchymal transition (EMT). Insight into the Nanog signaling cascade, upstream regulators and downstream effectors, is beginning to emerge but remains to be fully elucidated. This review highlights the current literature on the emerging role of Nanog in tumorigenesis and CSCs.
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影响因子：
8
作者：
Bourguignon, L. Y. W.;Earle, C.;Wong, G.;Spevak, C. C.;Krueger, K.
通讯作者：
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11.2
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DOI：
10.1007/s11596-012-0043-5
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影响因子：
8
作者：
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通讯作者：
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