Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats.
Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats.
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补充虎杖甙可改善饮食诱导的大鼠胰岛素抵抗和肝脂肪变性的发展。
DOI：
10.3892/mmr.2014.2708
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发表时间：
2015
影响因子：
3.4
通讯作者：
Yao, Fanrong
中科院分区：
文献类型：
--
作者：
Zhang, Qi;Tan, Yingying;Zhang, Nan;Yao, Fanrong
The pathophysiology of non-alcoholic fatty liver disease remains to be elucidated, and the currently available treatments are not entirely effective. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspidatum, has previously been demonstrated to possess hepatoprotective effects. The present study aimed to determine the effects of polydatin supplementation on hepatic fat accumulation and injury in rats fed a high-fat diet. In addition, the mechanisms underlying the protective effects of polydatin were examined. Male Sprague Dawley rats were randomly divided into four groups and received one of four treatment regimes for 12 weeks: Control diet, control diet supplemented with polydatin, high-fat diet, or high-fat diet supplemented with polydatin. Polydatin was supplemented in the drinking water at a concentration of 0.3% (wt/vol). The results of the present study showed that long-term high-fat feeding resulted in fatty liver in rats, which was manifested by excessive hepatic neutral fat accumulation and elevated plasma alanine aminotransferase and aspartate aminotransferase levels. Polydatin supplementation alleviated the hepatic pathological changes, and attenuated the insulin resistance, as shown by an improved homeostasis model assessment of basal insulin resistance values and a glucose tolerance test. Polydatin supplementation also corrected abnormal leptin and adiponectin levels. Specifically, polydatin supplementation enhanced insulin sensitivity in the liver, as shown by improved insulin receptor substrate 2 expression levels and Akt phosphorylation in the rat liver, following high-fat diet feeding. The results of the present study suggest that polydatin protects rats against high-fat feeding-induced insulin resistance and hepatic steatosis. Polydatin may be an effective hepatoprotective agent and a potential candidate for the prevention of fatty liver disease and insulin resistance.
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影响因子：
14.6
作者：
L. Adams;P. Angulo;K. Lindor
通讯作者：
L. Adams;P. Angulo;K. Lindor
DOI：
10.1016/j.bpg.2010.08.005
发表时间：
2010-10-01
影响因子：
3.2
作者：
Krawczyk, Marcin;Bonfrate, Leonilde;Portincasa, Piero
通讯作者：
Portincasa, Piero
DOI：
--
发表时间：
1998-12
期刊：
Alternative medicine review : a journal of clinical therapeutic
影响因子：
--
作者：
Scott Luper
通讯作者：
Scott Luper
DOI：
10.1007/978-3-319-11251-0_36
发表时间：
2016
期刊：
--
影响因子：
--
作者：
E. Smolle;S. Kessler;Nicole Golob;J. Haybaeck
通讯作者：
E. Smolle;S. Kessler;Nicole Golob;J. Haybaeck
DOI：
10.1007/978-1-4471-4715-2_9
发表时间：
2021-10
期刊：
Clinical Cases in Hepatology
影响因子：
--
作者：
N. Bergasa
通讯作者：
N. Bergasa