Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type.
Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type.
复制标题
胃底腺粘膜系上皮性肿瘤：与胃底腺型胃腺癌相关的新分类建议。
DOI：
10.1007/s00535-021-01813-z
复制
发表时间：
2021-09
影响因子：
6.3
通讯作者：
Nagahara A
中科院分区：
文献类型：
--
作者：
Ueyama H;Yao T;Akazawa Y;Hayashi T;Kurahara K;Oshiro Y;Yamada M;Oda I;Fujioka S;Kusumoto C;Fukuda M;Uchita K;Kadota T;Oono Y;Okamoto K;Murakami K;Matsuo Y;Kato M;Maehata T;Yahagi N;Yasuhara Y;Yada T;Uraushihara K;Yamane T;Matsuo T;Ito M;Maruyama Y;Osako A;Ono S;Kato M;Yagi K;Hashimoto T;Tomita N;Tsuyama S;Saito T;Matsumoto K;Matsumoto K;Watanabe S;Uemura N;Chiba T;Nagahara A
胃底腺型胃腺癌是胃肿瘤的一种罕见类型。然而，胃底腺粘膜系胃上皮性肿瘤（GEN-FGML; GA-FG相关肿瘤的通用术语）的病因、分类和临床病理特征尚未完全阐明。我们进行了一项大型、多中心、回顾性研究，以建立一个新的分类，并阐明GEN-FGML的临床病理特征。2008年至2019年期间，从35家机构收集了94例患者的100处GEN-FGML病变。我们设计了一个新的组织病理学分类GEN-FGML使用免疫组化分析和分析，通过临床病理学，免疫组化和遗传学评价。GEN-FGML分为泌酸腺腺瘤（OGA）、GA-FG和胃底腺粘膜型胃腺癌（GA-FGM）3种主要类型。此外，GA-FGM分为3个亚型：1型（暴露型组织化）、2型（暴露型组织化）和3型（非暴露型组织化）。OGA和GA-FG表现为低度上皮性肿瘤，GA-FGM应归类为GEN-FGML的侵袭性变体，表现为高度上皮性肿瘤（2型> 1，3）。在使用下一代测序的突变分析中，GNAS突变的频繁存在是GEN-FGML的特征性遗传特征（7/34，20.6%; OGA 1/3，33.3%; GA-FG 3/24，12.5%; GA-FGM 3/7，42.9%）。我们已经建立了一个新的组织病理学分类GEN-FGML，并提出了一个新的谱系胃上皮肿瘤，窝藏复发GNAS突变。这种分类将有助于评估GEN-FGML的恶性潜能，并建立适当的标准治疗方法。在线版本包含补充材料，可通过10.1007/s 00535 -021-01813-z获得。
Gastric adenocarcinoma of fundic-gland type (GA-FG) is a rare variant of gastric neoplasia. However, the etiology, classification, and clinicopathological features of gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML; generic term of GA-FG related neoplasm) are not fully elucidated. We performed a large, multicenter, retrospective study to establish a new classification and clarify the clinicopathological features of GEN-FGML. One hundred GEN-FGML lesions in 94 patients were collected from 35 institutions between 2008 and 2019. We designed a new histopathological classification of GEN-FGML using immunohistochemical analysis and analyzed via clinicopathological, immunohistochemical, and genetic evaluation. GEN-FGML was classified into 3 major types; oxyntic gland adenoma (OGA), GA-FG, and gastric adenocarcinoma of fundic-gland mucosa type (GA-FGM). In addition, GA-FGM was classified into 3 subtypes; Type 1 (organized with exposure type), Type 2 (disorganized with exposure type), and Type 3 (disorganized with non-exposure type). OGA and GA-FG demonstrated low-grade epithelial neoplasm, and GA-FGM should be categorized as an aggressive variant of GEN-FGML that demonstrated high-grade epithelial neoplasm (Type 2 > 1, 3). The frequent presence of GNAS mutation was a characteristic genetic feature of GEN-FGML (7/34, 20.6%; OGA 1/3, 33.3%; GA-FG 3/24, 12.5%; GA-FGM 3/7, 42.9%) in mutation analysis using next-generation sequencing. We have established a new histopathological classification of GEN-FGML and propose a new lineage of gastric epithelial neoplasm that harbors recurrent GNAS mutation. This classification will be useful to estimate the malignant potential of GEN-FGML and establish an appropriate standard therapeutic approach. The online version contains supplementary material available at 10.1007/s00535-021-01813-z.
登录
查看更多内容
影响因子：
--
作者：
Park ES;Kim YE;Park CK;Yao T;Kushima R;Kim KM
通讯作者：
Kim KM
对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
影响因子：
1.6
作者：
Takahashi K;Fujiya M;Ichihara S;Moriichi K;Okumura T
通讯作者：
Okumura T
影响因子：
1.6
作者：
Chen, Wei-Chung;Rodriguez-Waitkus, Paul M;McKechnie, John C
通讯作者：
McKechnie, John C
影响因子：
4.3
作者：
Lee, Tae-In;Jang, Jae-Young;Kim, Youn-Wha
通讯作者：
Kim, Youn-Wha