Tuning immunity through tissue mechanotransduction.
Tuning immunity through tissue mechanotransduction.
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DOI：
10.1038/s41577-022-00761-w
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发表时间：
2023-03
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影响因子：
--
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中科院分区：
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--
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免疫反应受来自组织微环境的信号支配，除了来自组织的生化信号、机械信号和力之外，其细胞外基质及其组成细胞塑造免疫细胞的功能。事实上，组织生物物理性质的变化改变了细胞在许多疾病条件下、在炎症状态下和在衰老背景下所经历的机械信号。这些机械信号通过机械转导过程转化为生化信号，在免疫细胞中发现了多种机械转导途径。这些途径影响重要的细胞功能，包括细胞激活、细胞因子的产生、代谢、增殖和运输。组织力学的变化也可能代表了一种新的“危险信号”，它提醒先天免疫系统和适应性免疫系统可能受到伤害或感染。组织力学可以在感染或炎症反应期间暂时改变，提供一种新的动态免疫调节层。在这里，我们回顾了机械免疫学的新兴领域，集中在组织环境规模的机械提示如何调节免疫细胞行为，以启动、传播和解决免疫反应。这篇综述讨论了组织的生物物理特性如何通过机械转导过程来塑造免疫细胞功能。在免疫细胞中有多种机械转导途径，作者强调了这些途径和机械免疫学的新兴领域。
Immune responses are governed by signals from the tissue microenvironment, and in addition to biochemical signals, mechanical cues and forces arising from the tissue, its extracellular matrix and its constituent cells shape immune cell function. Indeed, changes in biophysical properties of tissue alter the mechanical signals experienced by cells in many disease conditions, in inflammatory states and in the context of ageing. These mechanical cues are converted into biochemical signals through the process of mechanotransduction, and multiple pathways of mechanotransduction have been identified in immune cells. Such pathways impact important cellular functions including cell activation, cytokine production, metabolism, proliferation and trafficking. Changes in tissue mechanics may also represent a new form of ‘danger signal’ that alerts the innate and adaptive immune systems to the possibility of injury or infection. Tissue mechanics can change temporally during an infection or inflammatory response, offering a novel layer of dynamic immune regulation. Here, we review the emerging field of mechanoimmunology, focusing on how mechanical cues at the scale of the tissue environment regulate immune cell behaviours to initiate, propagate and resolve the immune response. This Review considers how the biophysical properties of a tissue are able to shape immune cell function through the process of mechanotransduction. There are multiple mechanotransduction pathways that operate in immune cells and the authors highlight these and the emerging field of mechanoimmunology.
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影响因子：
3
作者：
Altorki T;Muller W;Brass A;Cruickshank S
通讯作者：
Cruickshank S
影响因子：
29.4
作者：
Colecchia, Antonio;Montrone, Lucia;Festi, Davide
通讯作者：
Festi, Davide
DOI：
10.1083/jcb.201406120
发表时间：
2015-02-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Comrie WA;Li S;Boyle S;Burkhardt JK
通讯作者：
Burkhardt JK
DOI：
10.1186/s12952-015-0042-8
发表时间：
2015-01-01
期刊：
JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE
影响因子：
--
作者：
Acevedo-Acevedo, Suehelay;Crone, Wendy C.
通讯作者：
Crone, Wendy C.
DOI：
10.1039/c5ib00040h
发表时间：
2015-10
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Acerbi I;Cassereau L;Dean I;Shi Q;Au A;Park C;Chen YY;Liphardt J;Hwang ES;Weaver VM
通讯作者：
Weaver VM