Platelet "first responders" in wound response, cancer, and metastasis.
Platelet "first responders" in wound response, cancer, and metastasis.
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DOI：
10.1007/s10555-017-9682-0
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Honn KV
中科院分区：
文献类型：
--
作者：
Menter DG;Kopetz S;Hawk E;Sood AK;Loree JM;Gresele P;Honn KV
在正常的创伤和动态平衡过程中，血小板是“第一反应者”。无核血小板来源于骨髓干细胞系的巨核细胞，可影响炎症和免疫调节。在生物物理学上，由于大小和盘状形态的原因，血小板被优化，以分布在血管壁附近，监测血管完整性，并启动对血管损伤的快速反应。黏附受体连接到高活性的丝状支架生成细胞骨架，使其血管表面接触最大化，从而实现快速反应能力。在功能上，血小板通常启动快速凝血、血管收缩、炎症和伤口生物学，从而导致灭菌、组织修复和消退。血小板也是最先感知、吞噬、修饰循环中的病原体或对其做出反应的细胞之一。这些血小板第一反应特性在慢性炎症、癌症进展和转移过程中被征用。癌变过程中的渗漏或炎性反应血管生成为血小板侵入肿瘤提供了机会。癌症被认为是一种无法愈合的或慢性的伤口，可以积极地利用血小板的有丝分裂特性来刺激肿瘤的生长。这种生长最终超过了循环支持，导致血管生成和肿瘤细胞进入血流。循环中的肿瘤细胞与额外的血小板重新结合，促进肿瘤细胞的黏附、停滞、外渗和转移。这一过程以及与恶性肿瘤相关的高凝状态被肿瘤中IL6的产生放大，IL6刺激肝脏血小板生成素的产生，并通过骨髓中的血小板生成增加循环中的血小板数量。这些复杂的相互作用和血小板在不同生理应激过程中的“第一反应”作用提供了一个有用的治疗靶点，值得进一步探索。
Platelets serve as “First Responders” during normal wounding and homeostasis. Arising from bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence inflammation and immune regulation. Biophysically, platelets are optimized due to size and discoid morphology to distribute near vessel walls, monitor vascular integrity and initiate quick responses to vascular lesions. Adhesion receptors linked to a highly reactive filopodia-generating cytoskeleton maximizes their vascular surface contact allowing rapid response capabilities. Functionally, platelets normally initiate rapid clotting, vasoconstriction, inflammation and wound biology that leads to sterilization, tissue repair and resolution. Platelets also are among the first to sense, phagocytize, decorate, or react to pathogens in the circulation. These platelet first responder properties are commandeered during chronic inflammation, cancer progression and metastasis. Leaky or inflammatory reaction blood vessel genesis during carcinogenesis provides opportunities for platelet invasion into tumors. Cancer is thought of as a non-healing or chronic wound that can be actively aided by platelet mitogenic properties to stimulate tumor growth. This growth ultimately outstrips circulatory support leads to angiogenesis and intravasation of tumor cells into the blood stream. Circulating tumor cells reengage additional platelets, which facilitates tumor cell adhesion, arrest and extravasation and metastasis. This process, along with the hypercoagulable states associated with malignancy is amplified by IL6 production in tumors that stimulate liver thrombopoietin production and elevates circulating platelet numbers by thrombopoiesis in the bone marrow. These complex interactions and the “First Responder” role of platelets during diverse physiologic stresses provides a useful therapeutic target that deserves further exploration.
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影响因子：
--
作者：
Benazzi C;Al-Dissi A;Chau CH;Figg WD;Sarli G;de Oliveira JT;Gärtner F
通讯作者：
Gärtner F
影响因子：
168.9
作者：
Burn, John;Gerdes, Anne-Marie;Macrae, Finlay;Mecklin, Jukka-Pekka;Moeslein, Gabriela;Olschwang, Sylviane;Eccles, Diane;Evans, D. Gareth;Maher, Eamonn R.;Bertario, Lucio;Bisgaard, Marie-Luise;Dunlop, Malcolm G.;Ho, Judy W. C.;Hodgson, Shirley V.;Lindblom, Annika;Lubinski, Jan;Morrison, Patrick J.;Murday, Victoria;Ramesar, Raj;Side, Lucy;Scott, Rodney J.;Thomas, Huw J. W.;Vasen, Hans F.;Barker, Gail;Crawford, Gillian;Elliott, Faye;Movahedi, Mohammad;Pylvanainen, Kirsi;Wijnen, Juul T.;Fodde, Riccardo;Lynch, Henry T.;Mathers, John C.;Bishop, D. Timothy
通讯作者：
Bishop, D. Timothy
DOI：
10.1080/00365513.2017.1292538
发表时间：
2017-01-01
影响因子：
2.1
作者：
Biolik, Grzegorz;Kokot, Michal;Ziaja, Krzysztof
通讯作者：
Ziaja, Krzysztof
影响因子：
10.3
作者：
Bardia, Aditya;Ebbert, Jon O.;Cerhan, James R.
通讯作者：
Cerhan, James R.
影响因子：
4.1
作者：
Asselin, J;Knight, CG;Watson, SP
通讯作者：
Watson, SP