An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity.

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity.
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DOI:
10.1002/bies.201100187
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发表时间:
2012-10
期刊:
影响因子:
4
通讯作者:
Weis, William I.
Weis, William I.
中科院分区:
生物学3区
文献类型:
--
作者:
Dickinson, Daniel J.;Nelson, W. James;Weis, William I.

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后生动物(多细胞动物)的定义是极化上皮组织的存在,上皮形态发生有助于动物身体计划的多样性。最近在非后生动物社会阿米巴Dictyosteelium discoideum极化上皮的发现表明,上皮组织不是后生动物的独特特征,并质疑传统的观点,即多细胞性独立进化的社会阿米巴和后生动物。我们提出了另一种假设,动物,真菌和社会变形虫进化的祖先,花了一部分的生命周期中的多细胞状态,并拥有必要的形成上皮组织的分子机制。这一假说对后生动物近亲的组织结构做出了可检验的预测,并为早期动物进化的研究提供了一个新的概念框架。
Metazoans (multicellular animals) are defined by the presence of polarized epithelial tissues, and epithelial morphogenesis contributes to the diversity of animal body plans. The recent finding of a polarized epithelium in the non-metazoan social amoeba Dictyostelium discoideum demonstrates that an epithelial tissue is not a unique feature of metazoans and calls into question the traditional view that multicellularity evolved independently in social amoebae and metazoans. We propose the alternative hypothesis that animals, fungi and social amoebae evolved from an ancestor that spent a portion of its life cycle in a multicellular state and possessed molecular machinery necessary for forming an epithelial tissue. This hypothesis makes testable predictions regarding tissue organization in close relatives of metazoans and provides a novel conceptual framework for studies of early animal evolution.
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发表时间: 2012-09-11
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