Whole-brain voxel-based analysis of diffusion tensor MRI parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage.
Whole-brain voxel-based analysis of diffusion tensor MRI parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage.
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原发性开角型青光眼患者弥散张量MRI参数的全脑体素分析及其与临床青光眼分期的相关性
DOI：
10.1007/s00234-012-1122-9
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发表时间：
2013-02
期刊：
影响因子：
2.8
通讯作者：
Xu, Dongrong
中科院分区：
文献类型：
--
作者：
Dai, Hui;Yin, Dazhi;Hu, Chunhong;Morelli, John N.;Hu, Su;Yan, Xu;Xu, Dongrong
关键词：
青光眼是世界范围内第二大致盲性疾病。本研究的目的是确定区域的神经退行性青光眼利用3 T磁共振（MR）扩散张量成像（DTI）参数与全脑体素为基础的分析（SAFETY），并确定这些参数是否与疾病的严重程度。MethodsTwenty-five青光眼患者和25名年龄匹配的健康志愿者进行了前瞻性研究。使用静态阈值视野参数评估临床青光眼严重程度。所有受试者均接受3 T MRI，采用DTI序列（重复时间/回波时间13，000/68.9 ms，沿30个方向的最大b值800 s/mm 2）和解剖序列提供结构信息。所有数据集均由SPSS处理。比较两组的脑各向异性分数、平均扩散率（MD）、径向扩散率（RD）和轴向扩散率（AD）。结果青光眼患者的双侧视放射线和视交叉各向异性分数明显低于正常对照组（P< 0.05）。青光眼患者的视辐射RD同样降低（p< 0.05）。两组间MD和AD差异无统计学意义（p> 0.05）。视交叉各向异性分数值与青光眼分期呈负相关（r=-0.53，p = 0.05），视辐射RD值与青光眼分期呈正相关（左r = 0.45，p = 0.05;右r = 0.38，p = 0.06）。由于各向异性分数和RD也与青光眼分期相关，因此这些值可以作为疾病严重程度的潜在非侵入性标志物。
IntroductionGlaucoma is the second leading cause of blindness worldwide. The purpose of this study is to identify areas of neurodegeneration in glaucoma utilizing 3 T magnetic resonance (MR) diffusion tensor imaging (DTI) parameters with whole-brain voxel-based analysis (VBA) and determine whether these parameters correlate with disease severity.MethodsTwenty-five glaucoma patients and 25 age-matched healthy volunteers were prospectively examined. Clinical glaucoma severity was assessed utilizing static threshold visual field parameters. All subjects underwent 3 T MRI utilizing a DTI sequence (repetition time/echo time 13,000/68.9 ms, maximalbvalue 800 s/mm2along 30 directions) and an anatomic sequence to provide structural information. All data sets were processed by VBA. Brain fractional anisotropy, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were compared in the two groups. Correlation between DTI parameters and glaucoma stage were determined.ResultsThe bilateral optic radiations and chiasma of glaucoma patients demonstrated statistically significantly lower fractional anisotropy (p< 0.05). Optic radiation RD was similarly decreased in glaucoma patients (p< 0.05). There were no statistically significant differences noted in MD or AD between the two groups (p> 0.05). Optic chiasm fractional anisotropy values were negatively correlated with glaucoma stage (r= −0.53,p< 0.05) and optic radiation RD values positively correlated (leftr= 0.45,p< 0.05; right = 0.38,p= 0.06).ConclusionDTI parameters fractional anisotropy and RD are altered in the optic chiasm and radiations of glaucoma patients. As fractional anisotropy and RD also correlate with glaucoma stage, these values could serve as potential noninvasive markers of disease severity.
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影响因子：
2.5
作者：
El-Rafei, Ahmed;Engelhorn, Tobias;Michelson, Georg
通讯作者：
Michelson, Georg
影响因子：
4.8
作者：
Engelhorn, Tobias;Michelson, Georg;Doerfler, Arnd
通讯作者：
Doerfler, Arnd
影响因子：
9.9
作者：
Naismith, R. T.;Xu, J.;Song, S. -K.
通讯作者：
Song, S. -K.
影响因子：
5.7
作者：
Song, SK;Sun, SW;Neufeld, AH
通讯作者：
Neufeld, AH
影响因子：
5.7
作者：
Song, SK;Sun, SW;Cross, AH
通讯作者：
Cross, AH