Understanding the aetiology and resolution of chronic otitis media from animal and human studies.
Understanding the aetiology and resolution of chronic otitis media from animal and human studies.
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DOI：
10.1242/dmm.029983
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发表时间：
2017-11-01
影响因子：
4.3
通讯作者：
Cheeseman MT
中科院分区：
文献类型：
--
作者：
Bhutta MF;Thornton RB;Kirkham LS;Kerschner JE;Cheeseman MT
中耳炎，临床上称为慢性中耳炎，以不同的形式存在，例如慢性渗出性中耳炎（COME;胶耳）和慢性化脓性中耳炎（CSOM）。这些都是高度流行的疾病，尤其是在儿童时期，并导致全球范围内的严重发病率。然而，许多仍然不清楚这种疾病，包括其病因，开始和延续，粘膜和白细胞生物学，病原体和咽鼓管功能的相对作用。慢性中耳炎通常在小鼠中建模，但大多数现有模型仅部分模拟人类疾病，并且许多是综合征。然而，这些模型提供了对潜在疾病机制的见解，并涉及改变的免疫信号传导，粘膜纤毛功能和咽鼓管功能作为潜在的易感机制。慢性中耳炎的临床研究尚未涉及特定的分子途径或机制，目前的人类遗传学研究动力不足。我们也不完全了解现有的干预措施，如鼓膜修复，工作，也没有慢性中耳炎如何自发解决。这篇临床难题文章描述了我们目前对慢性中耳炎的了解以及这种情况的现有研究模型。它还确定了有关其发病机制和治疗的未回答的问题，旨在促进我们对这种疾病的理解，以帮助开发新的治疗干预措施。摘要：慢性中耳炎是一种常见病。动物模型，特别是小鼠模型，已被用于阐明一些潜在的机制，包括免疫信号传导，粘膜纤毛功能或咽鼓管功能的功能障碍。
Inflammation of the middle ear, known clinically as chronic otitis media, presents in different forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative otitis media (CSOM). These are highly prevalent diseases, especially in childhood, and lead to significant morbidity worldwide. However, much remains unclear about this disease, including its aetiology, initiation and perpetuation, and the relative roles of mucosal and leukocyte biology, pathogens, and Eustachian tube function. Chronic otitis media is commonly modelled in mice but most existing models only partially mimic human disease and many are syndromic. Nevertheless, these models have provided insights into potential disease mechanisms, and have implicated altered immune signalling, mucociliary function and Eustachian tube function as potential predisposing mechanisms. Clinical studies of chronic otitis media have yet to implicate a particular molecular pathway or mechanism, and current human genetic studies are underpowered. We also do not fully understand how existing interventions, such as tympanic membrane repair, work, nor how chronic otitis media spontaneously resolves. This Clinical Puzzle article describes our current knowledge of chronic otitis media and the existing research models for this condition. It also identifies unanswered questions about its pathogenesis and treatment, with the goal of advancing our understanding of this disease to aid the development of novel therapeutic interventions. Summary: Chronic middle ear inflammation is a common disease. Animal models, and in particular mouse models, have been used to elucidate some potential mechanisms, including dysfunction in immune signalling, mucociliary function or Eustachian tube function.
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影响因子：
2.6
作者：
Chan, Chun Ling;Wabnitz, David;Psaltis, Alkis James
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
Azar A;Piccinelli C;Brown H;Headon D;Cheeseman M
通讯作者：
Cheeseman M
影响因子：
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作者：
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通讯作者：
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影响因子：
4.6
作者：
Bhutta MF;Lambie J;Hobson L;Goel A;Hafrén L;Einarsdottir E;Mattila PS;Farrall M;Brown S;Burton MJ
通讯作者：
Burton MJ