Metamorphoses of malaria: the role of autophagy in parasite differentiation.
Metamorphoses of malaria: the role of autophagy in parasite differentiation.
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DOI：
10.1042/bse0510127
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发表时间：
2011
影响因子：
6.4
通讯作者：
Coppens I
中科院分区：
文献类型：
--
作者：
Coppens I
几种原生动物寄生虫经历复杂的生命周期，在无脊椎动物载体和脊椎动物宿主之间交替。寄生虫对这些不同环境的适应是通过其形态和代谢的急剧变化来实现的。疟疾寄生虫必须从蚊子传播到哺乳动物作为其生命周期的一部分。在进入哺乳动物宿主后，细胞外疟疾子孢子到达肝脏并侵入肝细胞，其中它们满足成为具有复制能力的宿主的挑战。在转化过程中，子孢子选择性地丢弃寄生虫在肝细胞中生长所不需要的细胞器。从子孢子中清除的细胞器中有微丝，这是一种丰富的分泌囊泡，有助于寄生虫粘附到肝细胞上。专门用于子孢子运动和结构的细胞器，如内膜复合物（运动寄生虫细胞骨架的主要组成部分），也从转化寄生虫中消除。在肝脏形态发育级联反应开始时发生的高度复杂的变态表明，观察到的变化必须是多因素的。在消除子孢子细胞器的机制中，称为自噬的降解过程有助于寄生虫内部的重塑和复制性肝形式的产生。在更广泛的背景下，在昆虫和脊椎动物之间循环的原生动物寄生虫分化过程中，自噬所发挥的作用的重要性现在已经清楚地显现出来。从这些观察中得出的一个令人兴奋的前景是，参与自噬过程的寄生虫蛋白可能代表药物开发的新靶点。
Several protozoan parasites undergo a complex lifecycle that alternates between an invertebrate vector and a vertebrate host. Adaptations to these different environments by the parasites are achieved by drastic changes in their morphology and metabolism. The malaria parasites must be transmitted to a mammal from a mosquito as part of their lifecycle. Upon entering the mammalian host, extracellular malaria sporozoites reach the liver and invade hepatocytes, wherein they meet the challenge of becoming replication-competent schizonts. During the process of conversion, the sporozoite selectively discards organelles that are unnecessary for the parasite growth in liver cells. Among the organelles that are cleared from the sporozoite are the micronemes, abundant secretory vesicles that facilitates the adhesion of the parasite to hepatocytes. Organelles specialized in sporozoite motility and structure, such as the inner membrane complex (a major component of the motile parasite’s cytoskeleton), are also eliminated from converting parasites. The high degree of sophistication of the metamorphosis that occurs at the onset of the liver form development cascade suggests that the observed changes must be multifactorial. Among the mechanisms implicated in the elimination of sporozoite organelles, the degradative process called autophagy contributes to the remodeling of parasite interior and the production of replicative liver forms. In a broader context, the importance of the role played by autophagy during the differentiation of protozoan parasites that cycle between insects and vertebrates is nowadays clearly emerging. An exciting prospect derived from these observations is that the parasite proteins involved in the autophagic process may represent new targets for drug development.
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影响因子：
3.6
作者：
MEIS, JFGM;VERHAVE, JP;MEUWISSEN, JHET
通讯作者：
MEUWISSEN, JHET
影响因子：
64.5
作者：
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通讯作者：
Ohsumi, Yoshinori
影响因子：
6.6
作者：
Takano-Ohmuro, H;Mukaida, M;Morioka, K
通讯作者：
Morioka, K
影响因子：
2.1
作者：
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通讯作者：
Inagaki, F
影响因子：
56.9
作者：
Sturm, Angelika;Amino, Rogerio;Heussler, Volker T.
通讯作者：
Heussler, Volker T.