Defining blood pressure goals: is it enough to manage total cardiovascular risk?
Defining blood pressure goals: is it enough to manage total cardiovascular risk?
复制标题
定义血压目标：是否足以管理总体心血管风险？
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
G. Mancia
中科院分区：
文献类型：
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作者：
G. Mancia
众所周知，降低高血压患者的血压与心血管保护有关。因此，国际高血压指南定义了血压目标（<140/90 mmHg； 2型糖尿病患者<130/80 mmHg）。然而，血压与预后的关系是复杂的，控制办公室血压可能不足以最佳地控制心血管总风险。越来越清楚的是，门诊外血压测量具有重要的预后价值。在动脉压监测协会的观察性研究中，11年内心血管死亡的风险随着办公室、家庭或动态血压升高10mmhg而逐渐升高。平稳控制24小时血压可能更为重要，因为清晨血压激增、夜间血压和血压变异性与重大风险相关。在控制心血管总风险时，需要进一步考虑使用多种抗高血压药物来控制血压。
It is well established that lowering blood pressure (BP) in patients with hypertension is associated with cardiovascular protection. Therefore, BP goals have been defined by international hypertension guidelines (<140/90 mmHg; <130/80 mmHg for patients with type 2 diabetes). However, the relationship of BP with prognosis is complex, and controlling office BP may not be enough to optimally manage total cardiovascular risk. It is becoming clear that out-of-office BP measurements have important prognostic value. In the observational Pressioni Arteriose Monitorate E Loro Associazioni study, the risk of cardiovascular death over 11 years was progressively higher with 10-mmHg increases in office, home, or ambulatory BPs. Smooth control of 24-h BP may be of even greater importance, as the early morning BP surge, nighttime BP, and BP variability are associated with significant risk. A further consideration in managing total cardiovascular risk is the need for multiple antihypertensive agents to control BP.
DOI：
10.1001/jama.1996.03530440037034
发表时间：
1996-05
期刊：
JAMA
影响因子：
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作者：
Daniel Levy;M. Larson;R. Vasan;W. Kannel
通讯作者：
Daniel Levy;M. Larson;R. Vasan;W. Kannel
影响因子：
158.5
作者：
Klag, MJ;Whelton, PK;Stamler, J
通讯作者：
Stamler, J
影响因子：
120.7
作者：
Pepine, CJ;Handberg, EM;Parmley, WW
通讯作者：
Parmley, WW