Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost.
Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost.
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DOI：
10.1080/22221751.2021.2022440
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发表时间：
2022-12
影响因子：
13.2
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Ai J;Zhang H;Zhang Y;Lin K;Zhang Y;Wu J;Wan Y;Huang Y;Song J;Fu Z;Wang H;Guo J;Jiang N;Fan M;Zhou Y;Zhao Y;Zhang Q;Liu Q;Lv J;Li P;Qiu C;Zhang W
新出现的新VOC B.1.1.529（Omicron）变体由于多个突变引起了严重关注，报告了显著的免疫逃逸和前所未有的快速传播速度。目前，仍然缺乏描述针对Omicron的不同同源和异源加强疫苗接种的中和能力的研究。在这项研究中，我们探索了COVID-19突破患者、BBIBP-CorV同源加强组和BBIBP-CorV/ZF 2001异源加强组对SARS-CoV-2假型（对应于原型、Beta、Delta和紧急Omicron变体）的免疫原性。值得注意的是，在两剂灭活疫苗后14天，pVNT滴度针对原型增加至67.4 GMT，针对β增加至8.85 GMT，针对δ增加至35.07 GMT，而针对Omicron的中和活性在80%的样品中低于定量下限。在BBIBP-CorV同源加强接种后第14天，pVNT的GMT针对原型、β、δ和Omicron显著增加至285.6、215.7、250.8、48.73，而在ZF 2001异源加强接种后第14天，pVNT的GMT针对原型、β、δ和Omicron显著增加至1436.00、789.6、1501.00、95.86、1501.00、1分别加强免疫接种后，100%的样品显示出针对Omicron的阳性中和活性，尽管在同源或异源疫苗加强免疫后14天与原型相比，针对Omicron的pVNT显著降低（5.86- 14.98倍）。总的来说，我们的研究表明，与原型和其他VOC相比，疫苗诱导的免疫保护可能更容易被Omicron逃脱。在两剂灭活全病毒体疫苗作为“引发”注射后，第三种异源蛋白亚单位疫苗和同源灭活疫苗加强剂可以提高对Omicron的中和作用。
The emerging new VOC B.1.1.529 (Omicron) variant has raised serious concerns due to multiple mutations, reported significant immune escape, and unprecedented rapid spreading speed. Currently, studies describing the neutralization ability of different homologous and heterologous booster vaccination against Omicron are still lacking. In this study, we explored the immunogenicity of COVID-19 breakthrough patients, BBIBP-CorV homologous booster group and BBIBP-CorV/ZF2001 heterologous booster group against SARS-CoV-2 pseudotypes corresponding to the prototype, Beta, Delta, and the emergent Omicron variant. Notably, at 14 days post two-dose inactivated vaccines, pVNT titre increased to 67.4 GMTs against prototype, 8.85 against Beta and 35.07 against Delta, while neutralization activity against Omicron was below the lower limit of quantitation in 80% of the samples. At day 14 post BBIBP-CorV homologous booster vaccination, GMTs of pVNT significantly increased to 285.6, 215.7, 250.8, 48.73 against prototype, Beta, Delta, and Omicron, while at day 14 post ZF2001 heterologous booster vaccination, GMTs of pVNT significantly increased to 1436.00, 789.6, 1501.00, 95.86, respectively. Post booster vaccination, 100% samples showed positive neutralization activity against Omicron, albeit illustrated a significant reduction (5.86- to 14.98-fold) of pVNT against Omicron compared to prototype at 14 days after the homologous or heterologous vaccine boosters. Overall, our study demonstrates that vaccine-induced immune protection might more likely be escaped by Omicron compared to prototypes and other VOCs. After two doses of inactivated whole-virion vaccines as the “priming” shot, a third heterologous protein subunit vaccine and a homologous inactivated vaccine booster could improve neutralization against Omicron.
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影响因子：
13.2
作者：
Zhang L;Li Q;Liang Z;Li T;Liu S;Cui Q;Nie J;Wu Q;Qu X;Huang W;Wang Y
通讯作者：
Wang Y
DOI：
10.1126/science.abf9302
发表时间：
2021-02-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Starr TN;Greaney AJ;Addetia A;Hannon WW;Choudhary MC;Dingens AS;Li JZ;Bloom JD
通讯作者：
Bloom JD
影响因子：
64.5
作者：
Garcia-Beltran WF;St Denis KJ;Hoelzemer A;Lam EC;Nitido AD;Sheehan ML;Berrios C;Ofoman O;Chang CC;Hauser BM;Feldman J;Roederer AL;Gregory DJ;Poznansky MC;Schmidt AG;Iafrate AJ;Naranbhai V;Balazs AB
通讯作者：
Balazs AB
影响因子：
64.8
作者：
Park, Jeong Min;Cao, Yuan;Jarillo-Herrero, Pablo
通讯作者：
Jarillo-Herrero, Pablo
影响因子：
14.8
作者：
Nie, Jianhui;Li, Qianqian;Wang, Youchun
通讯作者：
Wang, Youchun