The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.
The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.
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DOI：
10.1080/22221751.2021.2017757
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发表时间：
2022-12
影响因子：
13.2
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Zhang L;Li Q;Liang Z;Li T;Liu S;Cui Q;Nie J;Wu Q;Qu X;Huang W;Wang Y
OMICRON/BA.1的出现给抗击SARS-CoV-2带来了新的挑战。Spike蛋白的大量突变表明，其对现有新冠肺炎感染和疫苗引发的免疫保护的敏感性可能会发生改变。在本研究中，我们构建了假型SARS-CoV-2变异株Omicron。对28份感染SARS-CoV-2原始毒株的新冠肺炎恢复期患者血清标本进行了对假型OMICRON、其他关注变异株(VOC、α、β、伽玛、Delta)和感兴趣变异株(VOIS、Lambda、Mu)的敏感性检测。结果表明，这些血清对OMICRON的平均中和ED50值为66，约为D614G参考毒株(ED50VOI556)的8.4倍，而其它 = 和VOI型病毒的中和活性仅下降约1.20-4.5%。我们体外试验的发现表明，奥米克龙变异株可能导致更显著的逃避先前感染SARS-CoV-2甚至现有新冠肺炎疫苗所引起的免疫保护。
The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be altered. In this study, we constructed the pseudotyped SARS-CoV-2 variant Omicron. The sensitivity of 28 serum samples from COVID-19 convalescent patients infected with SARS-CoV-2 original strain was tested against pseudotyped Omicron as well as the other variants of concern (VOCs, Alpha, Beta, Gamma, Delta) and variants of interest (VOIs, Lambda, Mu). Our results indicated that the mean neutralization ED50 of these sera against Omicron decreased to 66, which is about 8.4-folds compared to the D614G reference strain (ED50 = 556), whereas the neutralization activity of other VOC and VOI pseudotyped viruses decreased only about 1.2–4.5-folds. The finding from our in vitro assay suggest that Omicron variant may lead to more significant escape from immune protection elicited by previous SARS-CoV-2 infection and perhaps even by existing COVID-19 vaccines.
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影响因子：
64.5
作者：
Li Q;Nie J;Wu J;Zhang L;Ding R;Wang H;Zhang Y;Li T;Liu S;Zhang M;Zhao C;Liu H;Nie L;Qin H;Wang M;Lu Q;Li X;Liu J;Liang H;Shi Y;Shen Y;Xie L;Zhang L;Qu X;Xu W;Huang W;Wang Y
通讯作者：
Wang Y
影响因子：
5.9
作者：
Zhang L;Cui Z;Li Q;Wang B;Yu Y;Wu J;Nie J;Ding R;Wang H;Zhang Y;Liu S;Chen Z;He Y;Su X;Xu W;Huang W;Wang Y
通讯作者：
Wang Y
DOI：
10.1126/science.abn4947
发表时间：
2022-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pulliam JRC;van Schalkwyk C;Govender N;von Gottberg A;Cohen C;Groome MJ;Dushoff J;Mlisana K;Moultrie H
通讯作者：
Moultrie H
影响因子：
13.2
作者：
Wang M;Zhang L;Li Q;Wang B;Liang Z;Sun Y;Nie J;Wu J;Su X;Qu X;Li Y;Wang Y;Huang W
通讯作者：
Huang W
影响因子：
64.5
作者：
Garcia-Beltran WF;Lam EC;St Denis K;Nitido AD;Garcia ZH;Hauser BM;Feldman J;Pavlovic MN;Gregory DJ;Poznansky MC;Sigal A;Schmidt AG;Iafrate AJ;Naranbhai V;Balazs AB
通讯作者：
Balazs AB