Iron stores of breastfed infants during the first year of life.
Iron stores of breastfed infants during the first year of life.
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DOI：
10.3390/nu6052023
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发表时间：
2014-05-21
期刊：
影响因子：
5.9
通讯作者：
Jeter JM
中科院分区：
文献类型：
--
作者：
Ziegler EE;Nelson SE;Jeter JM
出生铁禀赋提供铁在生命的最初几个月的增长。我们描述了低膳食铁供应条件下的铁禀赋。受试者是参与1至9个月的维生素D补充试验的婴儿。婴儿在入组时完全母乳喂养，但从4个月开始可以接受辅食，但不能接受配方奶粉。分别于术后1、2、4、5.5、7.5、9和12个月测定血浆铁蛋白（PF）和转铁蛋白受体（TfR）。1个月时PF范围为38 - 752 µg/L，与母体PF仅弱相关。PF随后下降，并在5.5个月时趋于平稳。除12个月外，女性PF显著高于男性PF。TfR随年龄增长而增加，并与PF呈负相关。PF和TfR一直持续到9个月。铁缺乏（PF < 10 µg/L）在4个月时开始出现，频率增加，直到9个月。患有ID的婴儿出生时具有低铁禀赋。我们的结论是，出生铁禀赋的大小是高度可变的，小禀赋的地方在6个月前的婴儿缺铁的风险。男孩的铁营养比女孩少，缺铁的风险也比女孩大。
The birth iron endowment provides iron for growth in the first months of life. We describe the iron endowment under conditions of low dietary iron supply. Subjects were infants participating in a trial of Vitamin D supplementation from 1 to 9 months. Infants were exclusively breastfed at enrollment but could receive complementary foods from 4 months but not formula. Plasma ferritin (PF) and transferrin receptor (TfR) were determined at 1, 2, 4, 5.5, 7.5, 9 and 12 months. At 1 month PF ranged from 38 to 752 µg/L and was only weakly related to maternal PF. PF declined subsequently and flattened out at 5.5 months. PF of females was significantly higher than PF of males except at 12 months. TfR increased with age and was inversely correlated with PF. PF and TfR tracked strongly until 9 months. Iron deficiency (PF < 10 µg/L) began to appear at 4 months and increased in frequency until 9 months. Infants with ID were born with low iron endowment. We concluded that the birth iron endowment is highly variable in size and a small endowment places infants at risk of iron deficiency before 6 months. Boys have smaller iron endowments and are at greater risk of iron deficiency than girls.
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影响因子：
8
作者：
Lott, DG;Zimmerman, MB;Widness, JA
通讯作者：
Widness, JA
影响因子：
7.1
作者：
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通讯作者：
Borch-Iohnsen, Berit
影响因子：
20.3
作者：
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通讯作者：
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影响因子：
7.1
作者：
Ziegler, Ekhard E.;Nelson, Steven E.;Jeter, Janice M.
通讯作者：
Jeter, Janice M.
影响因子：
3.8
作者：
Hay, G;Sandstad, B;Borch-Iohnsen, B
通讯作者：
Borch-Iohnsen, B