High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology
High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology
复制标题
Silene 中的高线粒体突变率与核介导的线粒体生理学变化有关
DOI：
10.1098/rsbl.2020.0450
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发表时间：
2020
期刊：
影响因子：
3.3
通讯作者：
Havird, Justin C.
中科院分区：
文献类型：
--
作者：
Weaver, Ryan J.;Carrion, Gina;Nix, Rachel;Maeda, Gerald P.;Rabinowitz, Samantha;Iverson, Erik N.;Thueson, Kiley;Havird, Justin C.
线粒体呼吸依赖于由线粒体和核基因组编码的蛋白质。线粒体DNA突变率的变化存在于真核生物中，尽管在某些谱系中线粒体突变率升高的功能后果仍然未被探索。在被子植物属Silene中，生态学上相似的物种具有“快”或“慢”的mtDNA突变率。在这里，我们研究了线粒体呼吸谱ofSilenemitochondria的线粒体DNA突变率升高的功能后果。种属间呼吸的总体水平相似。快种的呼吸效率比慢种低，对核编码的呼吸酶交替氧化酶（AOX）和辅助酶（DHex）的依赖高达48%以上，这些酶参与植物的胁迫反应。然而，并不是所有的快速物种都表现出这些趋势。一些酶的呼吸谱是相关的，最显着的AOX和DHex。我们的结论是，在MT生理学上的细微差异，MT突变率显着不同的沉默可能是在更高水平的生物组织相似的表型的基础上，背叛MT突变的后果。
Mitochondrial (mt) respiration depends on proteins encoded both by the mitochondrial and nuclear genomes. Variation in mt-DNA mutation rates exists across eukaryotes, although the functional consequences of elevated mt mutation rates in some lineages remain underexplored. In the angiosperm genusSilene, closely related, ecologically similar species have either ‘fast' or ‘slow' mt-DNA mutation rates. Here, we investigated the functional consequences of elevated mt-DNA mutation rates on mt respiration profiles ofSilenemitochondria. Overall levels of respiration were similar among Species. Fast species had lower respiration efficiency than slow species and relied up to 48% more on nuclear-encoded respiratory enzymes alternative oxidase (AOX) and accessory dehydrogenases (DHex), which participate in stress responses in plants. However, not all fast species showed these trends. Respiratory profiles of some enzymes were correlated, most notably AOX and DHex. We conclude that subtle differences in mt physiology amongSilenelineages with dramatically different mt mutation rates may underly similar phenotypes at higher levels of biological organization, betraying the consequences of mt mutations.
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影响因子：
3.5
作者：
Zsurka G;Peeva V;Kotlyar A;Kunz WS
通讯作者：
Kunz WS
DOI：
10.1073/pnas.84.24.9054
发表时间：
1987-12-01
影响因子：
11.1
作者：
WOLFE, KH;LI, WH;SHARP, PM
通讯作者：
SHARP, PM
影响因子：
10.7
作者：
Lynch, M
通讯作者：
Lynch, M
影响因子：
1.5
作者：
Lynch, M;Blanchard, JL
通讯作者：
Blanchard, JL
低温下替代氧化酶的缺乏会导致碳和氮代谢平衡的破坏，并导致拟南芥叶子中抗氧化防御系统的上调。
DOI：
--
发表时间：
2008
期刊：
Plant, Cell and Environment 31(In press)
影响因子：
--
作者：
Watanabe;C.
通讯作者：
C.