The extracellular matrix and ciliary signaling.
The extracellular matrix and ciliary signaling.
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DOI：
10.1016/j.ceb.2012.06.002
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发表时间：
2012-10
影响因子：
7.5
通讯作者：
Golemis, Erica A.
中科院分区：
文献类型：
--
作者：
Seeger-Nukpezah, Tamina;Golemis, Erica A.
初级纤毛像天线一样从细胞表面伸出，感知细胞环境中提供的机械和化学线索。在某些组织类型中，纤毛朝向管腔允许对流体流动作出响应;在其他组织类型中，例如骨，纤毛突出到细胞外基质中允许对压缩力作出响应。睫状膜含有Hedgehog、Wnt、Notch和其他有效生长因子的受体，并且在某些情况下还含有整联蛋白和钙粘蛋白家族成员，允许接收稳健范围的信号。由纤毛形成或功能缺陷引起的越来越多的纤毛病包括发育缺陷和慢性进行性疾病，如多囊肾病（PKD）;已经提出纤毛功能的变化支持癌症进展。最近的研究结果揭示了纤毛和细胞外基质（ECM）之间广泛的信号对话，在多种情况下与纤维化相关的纤毛缺陷。此外，越来越多的蛋白质已被定义为在控制纤毛和与ECM的粘着斑相互作用中具有多种作用，进一步协调功能。我们总结并讨论这些最新的发现。
The primary cilium protrudes like an antenna from the cell surface, sensing mechanical and chemical cues provided in the cellular environment. In some tissue types, ciliary orientation to lumens allows response to fluid flow; in others, such as bone, ciliary protrusion into the extracellular matrix allows response to compression forces. The ciliary membrane contains receptors for Hedgehog, Wnt, Notch, and other potent growth factors, and in some instances also harbors integrin and cadherin family members, allowing receipt of a robust range of signals. A growing list of ciliopathies, arising from deficient formation or function of cilia includes both developmental defects and chronic, progressive disorders such as polycystic kidney disease (PKD); changes in ciliary function have been proposed to support cancer progression. Recent findings have revealed extensive signaling dialog between cilia and extracellular matrix (ECM), with defects in cilia associated with fibrosis in multiple contexts. Further, a growing number of proteins have been defined as possessing multiple roles in control of cilia and focal adhesion interactions with the ECM, further coordinating functionality. We summarize and discuss these recent findings.
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影响因子：
3.5
作者：
Delous M;Hellman NE;Gaudé HM;Silbermann F;Le Bivic A;Salomon R;Antignac C;Saunier S
通讯作者：
Saunier S
影响因子：
11.8
作者：
Bershteyn, Marina;Atwood, Scott X.;Woo, Wei-Meng;Li, Mischa;Oro, Anthony E.
通讯作者：
Oro, Anthony E.
影响因子：
20.1
作者：
Egorova AD;Khedoe PP;Goumans MJ;Yoder BK;Nauli SM;ten Dijke P;Poelmann RE;Hierck BP
通讯作者：
Hierck BP
DOI：
10.1016/j.bbadis.2010.11.006
发表时间：
2011-10-01
影响因子：
6.2
作者：
Boucher, Catherine A.;Ward, Heather H.;Sandford, Richard N.
通讯作者：
Sandford, Richard N.
DOI：
10.1083/jcb.201006173
发表时间：
2010-11-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chapin HC;Caplan MJ
通讯作者：
Caplan MJ