Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.
Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.
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脆性组氨酸三联体基因的低表达与头颈鳞状细胞癌的高增殖相关。
DOI：
10.1016/s1368-8375(02)00022-2
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发表时间：
2003
期刊：
影响因子：
4.8
通讯作者：
J. Wennerberg
中科院分区：
文献类型：
--
作者：
H. Mineta;K. Miura;S. Takebayashi;K. Misawa;Y. Ueda;I. Suzuki;M. Ito;J. Wennerberg
在头颈部鳞状细胞癌（HNSCC）中，在一些染色体区域如3p、9p、11q、13q和17p中发现了频繁的杂合性缺失。脆性组氨酸三联体（脆性组氨酸三联体，FHIT）基因位于3p14.2，包含一个常见的脆性位点，是一种肿瘤抑制基因。我们使用免疫组织化学、western blot和逆转录聚合酶链反应检测了57例HNSCC患者。分析FHIT表达与临床病理特征（包括p53和Ki-67表达）的关系。免疫组化分析显示30例（53%）FHIT低表达，27例（47%）FHIT高表达。FHIT低表达与Ki-67高表达显著相关，表明FHIT低表达的肿瘤细胞具有侵袭性增殖。FHIT表达与年龄、性别、肿瘤大小、淋巴结状况、分期分型、组织学分级、p53表达、预后等临床特征无相关性。FHIT改变可能在HNSCC的癌症发展中起重要作用，但对预后没有影响。
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcriptase polymerase chain reaction. The association between FHIT expression and clinicopathologic characteristics including p53 and Ki-67 expressions was analyzed. Immunohistochemical analysis revealed 30 patients (53%) of low FHIT expression and 27 patients (47%) of high FHIT expression. Low FHIT expression significantly correlated with high Ki-67 expression, indicating that tumor cells with low FHIT expression can proliferate aggressively. No correlation was found between FHIT expression and clinical characteristics including age, gender, tumor size, lymph node status, stage grouping, histologic grade, p53 expression, and prognosis. FHIT alteration may play an important role in cancer development of HNSCC, however it did not contribute to the prognosis.
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影响因子：
2.9
作者：
Barnes, LD;Garrison, PN;Huebner, F
通讯作者：
Huebner, F
影响因子：
11.2
作者：
T. Druck;P. Hadaczek;Tie-bo Fu;M. Ohta;Z. Siprashvili;R. Baffa;M. Negrini;K. Kastury;M. L. Veronese;D. Rosen;J. Rothstein;P. Mccue;M. Cotticelli;H. Inoue;C. Croce;K. Huebner
通讯作者：
T. Druck;P. Hadaczek;Tie-bo Fu;M. Ohta;Z. Siprashvili;R. Baffa;M. Negrini;K. Kastury;M. L. Veronese;D. Rosen;J. Rothstein;P. Mccue;M. Cotticelli;H. Inoue;C. Croce;K. Huebner
影响因子：
11.2
作者：
Janet I. Lee;Jean-Charles Soria;Khaled A. Hassan;Diane Liu;Ximing Tang;Adel K. El-Naggar;W. K. Hong-W.
通讯作者：
Janet I. Lee;Jean-Charles Soria;Khaled A. Hassan;Diane Liu;Ximing Tang;Adel K. El-Naggar;W. K. Hong-W.
原发性肺肿瘤和具有 FHIT 基因异常的细胞系中缺乏 Fhit 蛋白。
影响因子：
11.2
作者：
Sozzi,G;Tornielli,S;Tagliabue,E;Sard,L;Pezzella,F;Pastorino,U;Minoletti,F;Pilotti,S;Ratcliffe,C;Veronese,ML;Goldstraw,P;Huebner,K;Croce,CM;Pierotti,MA
通讯作者：
Pierotti,MA
DOI：
10.1073/pnas.94.25.13771
发表时间：
1997-12-09
影响因子：
11.1
作者：
Siprashvili, Z;Sozzi, G;Huebner, K
通讯作者：
Huebner, K