Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery.

Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery.
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DOI:
10.1038/s41467-022-28640-x
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发表时间:
2022-02-22
影响因子:
16.6
通讯作者:
Cook MJ
Cook MJ
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Cao M;Galvis D;Vogrin SJ;Woods WP;Vogrin S;Wang F;Woldman W;Terry JR;Peterson A;Plummer C;Cook MJ

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对癫痫发作中神经动力学产生的相互作用进行建模具有挑战性,但对于提高癫痫手术的成功率很重要。根据生理证据开发的动态网络模型提供了对癫痫发作中快速演变的大脑网络的见解。该领域先前研究的一个局限性是依赖于侵入性皮层记录,并对可能涉及癫痫动力学的大脑区域进行有限的空间采样。在这里,我们提出虚拟颅内脑电图(ViEEG),它结合了非侵入性发作期脑磁图成像(MEG)、动态网络模型和虚拟切除技术。在这项概念验证研究中,我们表明仅从 MEG 重建的 ViEEG 信号保留了动态方法识别参与癫痫发作的大脑区域的关键时空特征。我们证明,非侵入性 ViEEG 方法可能比颅内脑电图 (iEEG) 具有一些优势。未来的工作可能旨在测试虚拟 iEEG 方法在癫痫外科治疗中的潜力。动态网络模型可以深入了解受癫痫发作影响的大脑网络。在这里,作者从非侵入性 MEG 记录中得出 ViEEG(虚拟颅内脑电图),该记录显示癫痫患者参与癫痫发作的大脑区域。
Modelling the interactions that arise from neural dynamics in seizure genesis is challenging but important in the effort to improve the success of epilepsy surgery. Dynamical network models developed from physiological evidence offer insights into rapidly evolving brain networks in the epileptic seizure. A limitation of previous studies in this field is the dependence on invasive cortical recordings with constrained spatial sampling of brain regions that might be involved in seizure dynamics. Here, we propose virtual intracranial electroencephalography (ViEEG), which combines non-invasive ictal magnetoencephalographic imaging (MEG), dynamical network models and a virtual resection technique. In this proof-of-concept study, we show that ViEEG signals reconstructed from MEG alone preserve critical temporospatial characteristics for dynamical approaches to identify brain areas involved in seizure generation. We show the non-invasive ViEEG approach may have some advantage over intracranial electroencephalography (iEEG). Future work may be designed to test the potential of the virtual iEEG approach for use in surgical management of epilepsy. Dynamic network models offer insight into brain networks affected by epileptic seizures. Here the authors derive ViEEG (virtual intracranial EEG) from non-invasive MEG recordings that show brain areas involved in seizure generation in patients with epilepsy.
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