Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment.
Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment.
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DOI：
10.4049/jimmunol.0803659
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Cook-Mills JM
中科院分区：
文献类型：
--
作者：
Berdnikovs S;Abdala-Valencia H;McCary C;Somand M;Cole R;Garcia A;Bryce P;Cook-Mills JM
报告指出，在哮喘和动脉粥样硬化的临床研究中，维生素E的α-生育酚异构体的抗炎功能的结果相互矛盾。这些看似不同的临床结果与这项研究中报道的维生素E亚型的新的未知特性是一致的。我们证明，异构体d-γ-生育酚可增加实验性哮喘的炎症反应。此外，d-γ-生育酚的浓度仅为d-α-生育酚的10%时，d-α-生育酚异构体的抗炎作用就消失了。生理浓度的精制生育酚的这些相反的免疫调节功能的机制不是通过调节几种细胞因子、趋化因子或黏附分子的表达，而是至少部分地通过调节白细胞募集过程中的内皮细胞信号来实现。维生素E异构体的这些相反的调节功能对维生素E研究的解释产生了影响。总之，我们对精制生育酚异构体的研究改变了我们对维生素E调节血管功能和哮喘的理解。
Reports indicate contradictory outcomes for anti-inflammatory functions of the α-tocopherol isoform of vitamin E in clinical studies of asthma and atherosclerosis. These seemingly disparate clinical results are consistent with novel unrecognized properties of isoforms of vitamin E reported in this study. We demonstrate that the isoform d-γ-tocopherol elevates inflammation in experimental asthma. Moreover, d-γ-tocopherol, at as little as 10% the concentration of d-α-tocopherol, ablates the anti-inflammatory benefit of the d-α-tocopherol isoform. A mechanism for these opposing immunoregulatory functions of purified tocopherols at physiological concentrations is not through modulation of expression of several cytokines, chemokines, or adhesion molecules, but is, at least in part, by regulation of endothelial cell signals during leukocyte recruitment. These opposing regulatory functions of vitamin E isoforms have impact on interpretations of vitamin E studies. In summary, our studies with purified tocopherol isoforms alter our understanding of vitamin E regulation of vascular function and asthma.
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影响因子：
20.3
作者：
Deem, TL;Cook-Mills, JM
通讯作者：
Cook-Mills, JM
影响因子：
4.4
作者：
Deem, Tracy L.;Abdala-Valencia, Hiam;Cook-Mills, Joan M.
通讯作者：
Cook-Mills, Joan M.
DOI：
10.1073/pnas.200357097
发表时间：
2000-10-10
影响因子：
11.1
作者：
Jiang, Q;Elson-Schwab, I;Ames, BN
通讯作者：
Ames, BN
影响因子：
14.2
作者：
Almqvist, Catarina;Garden, Frances;Marks, Guy B.
通讯作者：
Marks, Guy B.
影响因子：
4.1
作者：
Egger, T;Schuligoi, R;Sattler, W
通讯作者：
Sattler, W