Impact of the natural hormonal milieu on ventral striatal responses to appetitive cigarette smoking cues: A prospective longitudinal study.
Impact of the natural hormonal milieu on ventral striatal responses to appetitive cigarette smoking cues: A prospective longitudinal study.
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DOI：
10.1016/j.dadr.2022.100119
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发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
Wetherill, Reagan R
中科院分区：
文献类型：
--
作者：
Franklin, Teresa R;Spilka, Nathaniel H;Keyser, Heather;Maron, Melanie;Jagannathan, Kanchana;Wetherill, Reagan R
前瞻性纵向（月经周期阶段）吸烟线索神经影像学研究。女性在暴露于吸烟暗示期间的月经周期的3个阶段进行成像。激素状态得到生化证实。在卵泡晚期，纹状体对吸烟的反应最大。在卵泡早期，纹状体对吸烟的反应最少。雌性性激素雌二醇（E）和孕酮（P）刺激腹侧纹状体奖励通路。E升高腹侧纹状体多巴胺并加速药物提示的恢复，而P对药物相关行为具有相反的“保护”作用。我们推测，女性可能会表现出更大的腹侧纹状体的反应，吸烟线索（SC）在卵泡晚期的月经周期（MC）时，E是高的，不受阻碍的P，并减少在黄体晚期的反应时，P是高的。为了验证我们的假设，24名自然循环依赖性黄体生成素的女性在选定的时间点完成了3个MC过程中的功能磁共振（fMRI），以反映早期卵泡（低E和P; LEP，对照条件），晚期卵泡（高E，低P; HE）和中期黄体（高E，高P; HEP）MC阶段。在功能磁共振成像会议（抵消阶段），妇女暴露于SC与非SC视听剪辑。验证每个MC的排卵情况，并在治疗前获得激素水平。条件内的对比表明，腹侧纹状体对SC与非SC的脑反应在LEP期间可以忽略不计，在HE（p=0.009）和HP（p=0.016）期间更大。不同条件下的对比显示，HE和HEP的反应大于LEP（p=0.005），HE的反应大于HEP（p=0.049）。结果支持和扩展我们的回顾性横断面研究的激素环境对SC反应性的影响。结果具有临床相关性，因为它们可以指导新的，知情的和立即可翻译的治疗策略，这些策略可以潜在地减少自然骑自行车的女性的复发。
Prospective longitudinal (by menstrual cycle phase) smoking cue neuroimaging study. Women were imaged in 3 phases of the menstrual cycle during smoking cue exposure. Hormone status was biochemically confirmed. Ventral striatal responses to smoking cues were greatest during the late follicular phase. Ventral striatal responses to smoking cues were least during the early follicular phase. The female sex hormones estradiol (E) and progesterone (P) galvanize the ventral striatal reward pathway. E elevates ventral striatal dopamine and accelerates drug-cued reinstatement, while P has opposing ‘protective’ effects on drug-related behavior. We hypothesize that women may exhibit greater ventral striatal responses to smoking cues (SCs) during the late follicular phase of the menstrual cycle (MC) when E is high and unimpeded by P, and reduced responses during the late luteal phase when P is high. To test our hypothesis, 24 naturally cycling cigarette-dependent women completed functional magnetic resonance (fMRI) sessions over the course of 3 MCs at select time points to reflect the early follicular (low E and P; LEP, control condition), late follicular (high E, low P; HE) and mid-luteal (high E, high P; HEP) MC phases. During fMRI sessions (counterbalanced by phase), women were exposed to a SC versus nonSC audio-visual clip. Ovulation was verified for each MC, and hormone levels were acquired prior to sessions. Contrasts within conditions showed that ventral striatal brain responses to SCs versus nonSCs were negligible during LEP and greater during HE (p=0.009) and HP (p=0.016). Contrasts across conditions showed that HE and HEP had greater responses than LEP (p=0.005), and HE had greater responses than HEP (p=0.049). Results support and extend our retrospective cross-sectional study of the influence of the hormonal milieu on SC reactivity. Results are clinically relevant as they may guide novel, hormonally-informed and immediately translatable treatment strategies that can potentially reduce relapse in naturally cycling women.
影响因子：
1.5
作者：
Wetherill RR;Spilka NH;Maron M;Keyser H;Jagannathan K;Ely AV;Franklin TR
通讯作者：
Franklin TR