Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.
Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.
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DOI：
10.1016/j.conctc.2021.100738
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发表时间：
2021-03
影响因子：
1.5
通讯作者：
Franklin TR
中科院分区：
文献类型：
--
作者：
Wetherill RR;Spilka NH;Maron M;Keyser H;Jagannathan K;Ely AV;Franklin TR
与男性相比，女性会经历更严重的吸烟健康后果，戒烟难度更大，对尼古丁替代疗法的反应也更差。卵巢激素的波动，特别是雌二醇(E)和孕酮(P)，在吸烟提醒(即提示)期间对大脑和行为反应的影响可能是一个促成因素。我们实验室的结果表明，处于月经周期(MC)卵泡晚期的女性吸烟线索(SC)脆弱性增加，认知控制基础神经回路的功能连通性降低，可能使她们面临持续吸烟和复发的更大风险。这项研究的主要目的是检查和联系激素状态与大脑和行为反应的SCS在三个月的MC的过程中，自然骑自行车的妇女谁是长期吸烟。这项纵向的平衡研究收集了女性MC期间三个时间点对SC的大脑和行为反应。参与者完成心理和身体检查、生化激素验证访问，以及至少三次实验室/神经成像扫描访问。扫描访问包括在血氧水平依赖(BOLD)数据采集期间的10分钟SC任务，并被定为发生在卵泡早期(低E和P)、卵泡晚期(高E，与P无关)和黄体中期(高P，高E)。主要结果包括对SCs的大脑反应(与非SCs相比)、主观渴望、E和P激素水平以及对SCs的行为反应。这项研究解决了我们知识中的一个关键缺口：即自然荷尔蒙环境对大脑和对干细胞的行为反应的影响，干细胞是一种强大的复发触发因素。此外，这项研究将为人类性别差异研究人员提供路线图，他们必须考虑女性经常令人困惑的周期荷尔蒙波动。在戒断症状缓解后很长一段时间内，接触吸烟线索会导致复发。卵巢激素的波动可能会影响女性对吸烟暗示的反应。荷尔蒙状态将与大脑和行为对吸烟线索的反应有关。所描述的程序为性别差异研究人员提供了路线图。
Women experience more severe health consequences from smoking, have greater difficulty quitting, and respond less favorably to nicotine replacement therapy than men. The influence of fluctuating ovarian hormones, specifically estradiol (E) and progesterone (P), on brain and behavioral responses during exposure to smoking reminders (i.e., cues) may be a contributing factor. Results from our laboratory suggest that women in the late follicular phase of their menstrual cycle (MC) have enhanced smoking cue (SC) vulnerabilities and reduced functional connectivity in neurocircuitry underlying cognitive control, potentially placing them at greater risk for continued smoking and relapse. The primary aim of this study is to examine and link hormonal status with brain and behavioral responses to SCs over the course of three monthly MCs in naturally cycling women who are chronic cigarette smokers. This longitudinal, counterbalanced study collects brain and behavioral responses to SCs at three time points during a woman's MC. Participants complete psychological and physical examinations, biochemical hormonal verification visits, and at least three laboratory/neuroimaging scan visits. The scan visits include a 10-min SC task during blood oxygen level-dependent (BOLD) data acquisition and are timed to occur during the early follicular phase (low E and P), late follicular phase (high E, unopposed by P), and mid-luteal phase (high P, high E). The primary outcomes include brain responses to SCs (compared to non-SCs), subjective craving, E and P hormone levels, and behavioral responses to SCs. This study addresses a critical gap in our knowledge: namely, the impact of the natural hormonal milieu on brain and behavioral responses to SCs, a powerful relapse trigger. Additionally, this study will provide a roadmap for human sex differences researchers who are obliged to consider the often confounding cyclic hormonal fluctuations of women. Exposure to smoking cues contribute to relapse long after withdrawal symptoms abate. Ovarian hormone fluctuations may affect women's responses to smoking cues. Hormonal status will be linked with brain and behavioral responses to smoking cues. Procedures described provide a roadmap for sex difference researchers.
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影响因子：
4.2
作者：
Becker, Jill B.;McClellan, Michele L.;Reed, Beth Glover
通讯作者：
Reed, Beth Glover
影响因子：
3.4
作者：
Baker NL;Gray KM;Ramakrishnan V;Tomko RL;McClure EA;Carpenter MJ;Saladin ME
通讯作者：
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影响因子：
6
作者：
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通讯作者：
Hatsukami, Dorothy
影响因子：
3.3
作者：
Colzato, L. S.;Hertsig, G.;Hommel, B.
通讯作者：
Hommel, B.
影响因子：
5.8
作者：
Bao, AM;Liu, RY;Zhou, JN
通讯作者：
Zhou, JN