Molecular mechanisms regulating hepcidin revealed by hepcidin disorders.
Molecular mechanisms regulating hepcidin revealed by hepcidin disorders.
复制标题
DOI：
10.1100/tsw.2011.130
复制
发表时间：
2011-07-07
影响因子：
--
通讯作者：
Silvestri L
中科院分区：
文献类型：
--
作者：
Camaschella C;Silvestri L
Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic level, iron homeostasis is regulated by the liver peptide hepcidin. Disruption of these regulatory loops leads to genetic diseases characterized by iron deficiency (iron-refractory iron-deficiency anemia) or iron overload (hemochromatosis). Alterations of the same systems are also found in acquired disorders, such as iron-loading anemias characterized by ineffective erythropoiesis and anemia of chronic diseases (ACD) associated with common inflammatory conditions. In ACD, iron is present in the body, but maldistributed, being deficient for erythropoiesis, but sequestered in macrophages. Studies of the hepcidin regulation by iron and inflammatory cytokines are revealing new pathways that might become targets of new therapeutic intervention in iron disorders.
登录
查看更多内容
影响因子：
20.3
作者：
Drakesmith, H;Schimanski, LM;Townsend, ARM
通讯作者：
Townsend, ARM
影响因子：
29
作者：
Donovan, A;Lima, CA;Andrews, NC
通讯作者：
Andrews, NC
影响因子：
20.3
作者：
Finberg, Karin E.;Whittlesey, Rebecca L.;Andrews, Nancy C.
通讯作者：
Andrews, Nancy C.
影响因子：
20.3
作者：
Falzacappa, Maria Vittoria Verga;Spasic, Maja Vujic;Muckenthaler, Martina U.
通讯作者：
Muckenthaler, Martina U.
影响因子：
20.3
作者：
Ganz, Tomas;Olbina, Gordana;Westerman, Mark
通讯作者：
Westerman, Mark