Intake and Sources of Dietary Fiber, Inflammation, and Cardiovascular Disease in Older US Adults.
Intake and Sources of Dietary Fiber, Inflammation, and Cardiovascular Disease in Older US Adults.
复制标题
美国老年人的饮食纤维，炎症和心血管疾病的摄入量和来源。
DOI：
10.1001/jamanetworkopen.2022.5012
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发表时间：
2022-03-01
影响因子：
13.8
通讯作者：
Mukamal KJ
中科院分区：
文献类型：
--
作者：
Shivakoti R;Biggs ML;Djoussé L;Durda PJ;Kizer JR;Psaty B;Reiner AP;Tracy RP;Siscovick D;Mukamal KJ
总纤维和纤维来源与炎症的关系是什么？炎症是否介导了谷物纤维摄入量与心血管疾病之间的负相关？在这项4125名患者的队列研究中，较高的总纤维和谷物纤维摄入量与较低的炎症相关。在观察到的谷物纤维与心血管疾病的负相关中，炎症介导了大约六分之一。炎症可能在介导观察到的谷物纤维摄入量与心血管疾病之间的负相关性方面发挥适度的作用;然而，谷物纤维可能在减少全身炎症方面发挥作用，这需要在未来的研究中进行测试。这项队列研究评估了来自心血管健康研究的老年患者中总纤维和纤维来源与炎症之间的关系。较高的膳食纤维摄入量与较低的炎症有关，但迄今为止尚未研究膳食纤维来源（即谷物，蔬菜或水果）之间的这种关联是否存在差异。评估总纤维摄入量和来源（即谷物，蔬菜和水果纤维摄入量）与炎症的关系，并评估炎症是否介导膳食纤维摄入量和心血管疾病（CVD）之间的负相关。在一项正在进行的美国队列研究中，在4125名年龄在65岁或以上的成年人的基线访视（1989-1990年）时，通过食物频率问卷对入组时无CVD（中风和心肌梗死）的研究参与者的饮食摄入进行评估。用炎症标志物的免疫测定法从基线时收集的血液样品中评估炎症。多变量线性回归模型测试了膳食纤维摄入量与炎症的关系。还评估了2015年6月之前，来自主成分分析的每种炎症标志物及其复合物是否介导了基线谷物纤维摄入量与CVD（中风、心肌梗死和动脉粥样硬化性心血管死亡）发生的相关性。分析了1989年6月1日至2015年6月30日的数据。总纤维摄入量和纤维来源（谷物，蔬菜和水果）。全身炎症标志物。心血管疾病是中介分析的结局。在4125名受试者中，0.1%（n = 3）为亚洲人或太平洋岛民，4.4%（n = 183）为黑人，0.3%（n = 12）为美洲原住民，95.0%（n = 3918）为白色，0.2%（n = 9）被归类为其他。在这4125人中，（2473名女性[60%];平均[SD]年龄，72.6 [5.5]岁; 183名黑人[4.4%];和3942名其他种族和族裔的人[95.6%] [即，黑人以外的种族和族裔，由参与者自我分类]），总纤维摄入量增加5 g/d与C反应蛋白浓度显著降低相关（校正均值差，−0.05 SD; 95% CI，−0.08至−0.01 SD; P = .007）和白细胞介素1受体拮抗剂（校正平均差异，-0.04 SD; 95% CI，-0.07至-0.01 SD; P < .02），但可溶性CD 163浓度较高（校正平均差异，0.05 SD; 95% CI，0.02-0.09 SD; P = .005）。在纤维来源中，只有谷物纤维始终与较低的炎症相关。同样，谷物纤维摄入量与较低的CVD发病率相关（调整后的风险比，0.90; 95%CI，0.81-1.00; 1941例发病病例）。观察到的谷物纤维与炎症标志物介导的CVD相关性的比例范围为白细胞介素18的1.5%至C反应蛋白的14.2%，以及其主要主成分的16.1%。这项研究的结果表明，谷物纤维摄入量与各种炎症标志物水平较低和CVD风险较低有关，炎症介导了谷物纤维摄入量与CVD之间约六分之一的相关性。
What are the associations of total fiber and fiber source with inflammation, and does inflammation mediate the inverse association between cereal fiber intake and cardiovascular disease? In this cohort study of 4125 patients, higher total fiber and cereal fiber intakes were associated with lower inflammation. Inflammation mediated approximately one-sixth of the observed inverse association of cereal fiber with cardiovascular disease. Inflammation may play a modest role in mediating the observed inverse association between cereal fiber intake and cardiovascular disease; nevertheless, cereal fiber may have a role in attempts to reduce systemic inflammation, which will need to be tested in future studies. This cohort study evaluates the association between total fiber and fiber source and inflammation in older patients from the Cardiovascular Health Study. Higher intake of dietary fiber has been associated with lower inflammation, but whether there are differences in this association by source of dietary fiber (ie, cereal, vegetable, or fruit) has not been studied to date. To evaluate the associations of total fiber intake and source (ie, cereal, vegetable, and fruit fiber intake) with inflammation and to evaluate whether inflammation mediates the inverse association between dietary fiber intake and cardiovascular disease (CVD). At the baseline visit (1989-1990) of 4125 adults aged 65 years or older in an ongoing US cohort study, dietary intake was assessed by a food frequency questionnaire among study participants without prevalent CVD (stroke and myocardial infarction) at enrollment. Inflammation was assessed from blood samples collected at baseline with immunoassays for markers of inflammation. Multivariable linear regression models tested the association of dietary fiber intake with inflammation. Also assessed was whether each inflammatory marker and its composite derived from principal component analysis mediated the association of baseline cereal fiber intake with development of CVD (stroke, myocardial infarction, and atherosclerotic cardiovascular death) through June 2015. Data from June 1, 1989, through June 30, 2015, were analyzed. Total fiber intake and sources of fiber (cereal, vegetable, and fruit). Systemic markers of inflammation. Cardiovascular disease was the outcome in the mediation analysis. Of 4125 individuals, 0.1% (n = 3) were Asian or Pacific Islander, 4.4% (n = 183) were Black, 0.3% (n = 12) were Native American, 95.0% (n = 3918) were White, and 0.2% (n = 9) were classified as other. Among these 4125 individuals (2473 women [60%]; mean [SD] age, 72.6 [5.5] years; 183 Black individuals [4.4%]; and 3942 individuals of other races and ethnicitites [95.6%] [ie, race and ethnicity other than Black, self-classified by participant]), an increase in total fiber intake of 5 g/d was associated with significantly lower concentrations of C-reactive protein (adjusted mean difference, −0.05 SD; 95% CI, −0.08 to −0.01 SD; P = .007) and interleukin 1 receptor antagonist (adjusted mean difference, −0.04 SD; 95% CI, −0.07 to −0.01 SD; P < .02) but with higher concentrations of soluble CD163 (adjusted mean difference, 0.05 SD; 95% CI, 0.02-0.09 SD; P = .005). Among fiber sources, only cereal fiber was consistently associated with lower inflammation. Similarly, cereal fiber intake was associated with lower CVD incidence (adjusted hazard ratio, 0.90; 95% CI, 0.81-1.00; 1941 incident cases). The proportion of the observed association of cereal fiber with CVD mediated by inflammatory markers ranged from 1.5% for interleukin 18 to 14.2% for C-reactive protein, and 16.1% for their primary principal component. Results of this study suggest that cereal fiber intake was associated with lower levels of various inflammatory markers and lower risk of CVD and that inflammation mediated approximately one-sixth of the association between cereal fiber intake and CVD.
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DOI：
10.1161/atvbaha.112.300421
发表时间：
2013-01
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Reiner AP;Lange EM;Jenny NS;Chaves PH;Ellis J;Li J;Walston J;Lange LA;Cushman M;Tracy RP
通讯作者：
Tracy RP
影响因子：
9.8
作者：
Kaczmarczyk, Melissa M.;Miller, Michael J.;Freund, Gregory G.
通讯作者：
Freund, Gregory G.
DOI：
10.1161/atvbaha.115.305289
发表时间：
2015-10
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Durda P;Sabourin J;Lange EM;Nalls MA;Mychaleckyj JC;Jenny NS;Li J;Walston J;Harris TB;Psaty BM;Valdar W;Liu Y;Cushman M;Reiner AP;Tracy RP;Lange LA
通讯作者：
Lange LA
影响因子：
13.8
作者：
Ahmad, Shafqat;Moorthy, M. Vinayaga;Mora, Samia
通讯作者：
Mora, Samia
DOI：
10.1093/gerona/gly075
发表时间：
2019-01-01
影响因子：
5.1
作者：
Sanders, Jason L.;Arnold, Alice M.;Newman, Anne B.
通讯作者：
Newman, Anne B.