The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer.
The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer.
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DOI：
10.1016/j.metabol.2012.01.017
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发表时间：
2012-08
影响因子：
9.8
通讯作者：
Freund, Gregory G.
中科院分区：
文献类型：
--
作者：
Kaczmarczyk, Melissa M.;Miller, Michael J.;Freund, Gregory G.
膳食纤维(DF)被认为是健康饮食的关键成分。DF不是不可消化的植物物质的静态集合，它们原封不动地或不受阻碍地通过胃肠道；相反，DFS是大量复杂的糖基分子，可以结合潜在的营养物质和营养前体，以防止它们被吸收。一些DFS是可发酵的，GI道的分解代谢导致各种生物活性物质的产生，如短链脂肪酸(SCFAs)，可以显著增加GI道的生物量，改变GI道菌群的组成。DFS的健康益处包括预防和缓解2型糖尿病、心血管疾病和结肠癌。通过调节食物的摄取、消化、吸收和代谢，DFS可降低患高脂血症、高胆固醇血症和高血糖的风险。新出现的研究已经开始研究DFS在免疫调节中的作用。如果得到证实，DFS可以促进许多生物过程，包括预防感染和改善情绪和记忆。本文综述了DFS公认的生理功能，并探索了其潜在的新的基于免疫的作用。
Dietary fiber (DF) is deemed to be a key component in healthy eating. DF is not a static collection of undigestible plant materials that pass untouched or unencumbered through the gastrointestinal (GI) tract; instead, DFs are a vast array of complex saccharide-based molecules that can bind potential nutrients and nutrient precursors to prevent their absorption. Some DFs are fermentable, and the GI tract catabolism leads to the generation of various bioactive materials, such as short-chain fatty acids (SCFAs), that can markedly augment the GI tract biomass and change the composition of the GI tract flora. The health benefits of DFs include the prevention and mitigation of type 2 diabetes, cardiovascular disease and colon cancer. By modulating food ingestion, digestion, absorption and metabolism, DFs reduce the risk of hyperlipidemia, hypercholesterolemia and hyperglycemia. Emerging research has begun to investigate the role of DFs in immunomodulation. If substantiated, DFs could facilitate many biologic processes, including infection prevention and the improvement of mood and memory. This review describes the accepted physiologic functions of DFs and explores their new potential immune-based actions.
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