Mechanisms of Clock Output in the Drosophila Circadian Pacemaker System
Mechanisms of Clock Output in the Drosophila Circadian Pacemaker System
复制标题
果蝇昼夜节律起搏器系统的时钟输出机制
DOI：
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复制
发表时间：
2006
影响因子：
3.5
通讯作者：
O. Shafer
中科院分区：
文献类型：
--
作者：
P. Taghert;O. Shafer
生物钟基础的分子振荡耦合到不同的输出信号，通过这些信号，下游事件中的每日节律被诱发和/或同步。在这里，作者回顾了描述果蝇昼夜节律输出机制的文献。他们开始在最近的水平，在振荡细胞本身，通过调查研究的节奏基因表达在果蝇头部。接下来，作者描述了构成节律性运动活动基础的昼夜节律起搏器网络的几个神经元群，并详细介绍了该网络如何组织和协调的当前模型。作者概述了描述神经肽色素分散因子（PDF）在果蝇大脑中作为昼夜节律递质的作用的证据。最后，在PDF的背景下，他们考虑了从昼夜节律起搏器网络到下游神经元和非神经元细胞的信号传导机制的研究，这些神经元和非神经元细胞直接控制节律输出。
Molecular oscillations that underlie the circadian clock are coupled to different output signals by which daily rhythms in downstream events are evoked and/or synchronized. Here the authors review the literature that describes circadian output mechanisms in Drosophila. They begin at the most proximal level, within oscillator cells themselves, by surveying studies of rhythmic gene expression within Drosophila heads. Next the authors describe the several neuron groups that compose the circadian pacemaker network underlying rhythmic locomotor activity, and they detail current models of how that network is organized and coordinated. The authors outline the body of evidence that describes a role for the neuropeptide pigment dispersing factor (PDF) as a circadian transmitter in the fly brain. Finally, in the context of PDF, they consider studies that address mechanisms of signaling from the circadian pacemaker network to downstream neurons and nonneuronal cells that directly control rhythmic outputs.
影响因子：
64.5
作者：
S. Renn;Jae H. Park;M. Rosbash;Jeffrey C. Hall;P. Taghert
通讯作者：
S. Renn;Jae H. Park;M. Rosbash;Jeffrey C. Hall;P. Taghert
影响因子：
56.9
作者：
de la Iglesia, HO;Meyer, J;Schwartz, WJ
通讯作者：
Schwartz, WJ
DOI：
10.1002/(sici)1097-4695(20000605)43:3
发表时间：
2000-06-05
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Kaneko, M;Park, JH;Hall, JC
通讯作者：
Hall, JC