Application of polymeric nanoparticles and micelles in insulin oral delivery.
Application of polymeric nanoparticles and micelles in insulin oral delivery.
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DOI：
10.1016/j.jfda.2015.01.007
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发表时间：
2015-09
影响因子：
3.6
通讯作者：
Pingale, Shailaja Suresh
中科院分区：
文献类型：
--
作者：
Alai, Milind Sadashiv;Lin, Wen Jen;Pingale, Shailaja Suresh
糖尿病是一种内分泌疾病，胰腺不能产生足够的胰岛素，或者身体不能有效地利用它产生的胰岛素。胰岛素治疗已成为糖尿病临床治疗的最佳选择。目前的胰岛素治疗是通过皮下注射，这往往不能模仿正常个体的葡萄糖稳态。这激发了许多开发安全有效的无创胰岛素输送途径的尝试。口服给药是最方便的给药途径。然而，胰岛素不能很好地口服吸收，因为它在胃肠道中的酶降解很快。因此，纳米颗粒载体如聚合物纳米颗粒和胶束被用于口服胰岛素递送。这些纳米载体保护胰岛素免受降解，并通过跨细胞和/或细胞旁途径促进胰岛素摄取。本文就纳米颗粒和胶束在胰岛素口服给药中的应用作一综述。并对近年来的研究进展进行了综述。
Diabetes mellitus is an endocrine disease in which the pancreas does not produce sufficient insulin or the body cannot effectively use the insulin it produces. Insulin therapy has been the best choice for the clinical management of diabetes mellitus. The current insulin therapy is via subcutaneous injection, which often fails to mimic the glucose homeostasis that occurs in normal individuals. This provokes numerous attempts to develop a safe and effective noninvasive route for insulin delivery. Oral delivery is the most convenient administration route. However, insulin cannot be well absorbed orally because of its rapid enzymatic degradation in the gastrointestinal tract. Therefore, nanoparticulate carriers such as polymeric nanoparticles and micelles are employed for the oral delivery of insulin. These nanocarriers protect insulin from degradation and facilitate insulin uptake via a transcellular and/or paracellular pathway. This review article focuses on the application of nanoparticles and micelles in insulin oral delivery. The recent advances in this topic are also reviewed.
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