Synapse-to-nucleus signaling.

Synapse-to-nucleus signaling.
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DOI:
10.1016/j.conb.2011.01.011
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发表时间:
2011-04
影响因子:
5.7
通讯作者:
Martin KC
Martin KC
中科院分区:
医学2区
文献类型:
--
作者:
Ch'ng TH;Martin KC

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神经元远端亚细胞区室产生的信号通常必须长距离传输到细胞核,以触发基因表达的变化。这种逆行信号对于神经回路的发育、功能和生存至关重要,神经元已经进化出多种机制来长距离传输信号。在这篇综述中,我们简要总结了将远端产生的信号传输到神经元核的一系列机制。然后,我们关注神经元可塑性期间可溶性信号从突触到细胞核的传输。
Signals generated in distal subcellular compartments of neurons must often travel long distances to the nucleus to trigger changes in gene expression. This retrograde signaling is critical to the development, function and survival of neural circuits, and neurons have evolved multiple mechanisms to transmit signals over long distances. In this review, we briefly summarize the range of mechanisms whereby distally-generated signals are transported to neuronal nuclei. We then focus on the transport of soluble signals from the synapse to the nucleus during neuronal plasticity.
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