Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors.
Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors.
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DOI：
10.1016/j.molcel.2013.12.020
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发表时间：
2014-02-06
期刊：
影响因子：
16
通讯作者：
Holdsworth, Michael J.
中科院分区：
文献类型：
--
作者：
Gibbs, Daniel J.;Isa, Nurulhikma Md;Movahedi, Mahsa;Lozano-Juste, Jorge;Mendiondo, Guillermina M.;Berckhan, Sophie;Marin-de la Rosa, Nora;Conde, Jorge Vicente;Correia, Cristina Sousa;Pearce, Simon P.;Bassel, George W.;Hamali, Bulut;Talloji, Prabhavathi;Tome, Daniel F. A.;Coego, Alberto;Beynon, Jim;Alabadi, David;Bachmair, Andreas;Leon, Jose;Gray, Julie E.;Theodoulou, Frederica L.;Holdsworth, Michael J.
一氧化氮（NO）是原核生物和真核生物中重要的信号物质。在植物中，NO调节关键的发育转变和胁迫反应。在这里，我们确定了一种机制，NO传感，协调整个发展的基础上有针对性的降解植物特异性转录调节因子，第七组乙烯反应因子（ERFs）的反应。我们表明，N-末端规则的有针对性的蛋白质水解途径的目标，这些蛋白质的破坏在NO的存在下，我们建立他们作为关键的监管机构的不同NO调节过程，包括种子萌发，气孔关闭，和下胚轴伸长。此外，我们定义的分子机制，NO控制发芽和串扰脱落酸（阿坝）信号通过ERF调控表达脱落酸不敏感5（ABI 5）。我们的工作演示了如何通过直接调节转录因子的稳定性将NO传感集成到多个生理过程中，并将第VII组ERFs确定为植物中气体信号感知的中心枢纽。我们阐明了一个一般的分子机制，在植物中一氧化氮传感器组VII ERFs通过N端规则途径作为一氧化氮传感器组VII ERFs被证明介导一氧化氮和脱落酸之间的串扰N端规则通过组VII ERFs调节一氧化氮稳态Gibbs et al.报道了通过N-末端规则途径介导的第VII组ERF转录因子的NO依赖性降解介导NO感测和信号转导，鉴定了这些转录因子作为植物中气体信号感知的中心枢纽。
Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants. We elucidate a general molecular mechanism for nitric oxide sensing in plants Group VII ERFs act as nitric oxide sensors via the N-end rule pathway Group VII ERFs are shown to mediate crosstalk between nitric oxide and abscisic acid The N-end rule regulates nitric oxide homeostasis through group VII ERFs Gibbs et al. report that NO-dependent degradation of group VII ERF transcription factors by the N-end rule pathway mediates NO sensing and signal transduction, identifying these transcription factors as central hubs for the perception of gaseous signals in plants.
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影响因子：
6.5
作者：
Blokhina, Olga;Fagerstedt, Kurt V.
通讯作者：
Fagerstedt, Kurt V.
DOI：
10.1073/pnas.94.11.5961
发表时间：
1997-05-27
影响因子：
11.1
作者：
Buttner, M;Singh, KB
通讯作者：
Singh, KB
影响因子：
7.2
作者：
Clough, SJ;Bent, AF
通讯作者：
Bent, AF
影响因子：
2.1
作者：
Irizarry, RA;Hobbs, B;Speed, TP
通讯作者：
Speed, TP
影响因子：
5.6
作者：
Kovacs I;Lindermayr C
通讯作者：
Lindermayr C