Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects.
Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects.
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DOI：
10.1111/j.2040-1124.2010.00078.x
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发表时间：
2011-06-05
影响因子：
3.2
通讯作者：
Inagaki N
中科院分区：
文献类型：
--
作者：
Harada N;Hamasaki A;Yamane S;Muraoka A;Joo E;Fujita K;Inagaki N
目的/前言： 胃抑制多肽和胰升糖素样肽-1是促进胰腺β细胞分泌胰岛素的主要胰岛素。导致胰岛素分泌的因素在高加索人中已有报道，但在日本人中还没有得到彻底的评估。在日本正常糖耐量(NGT)受试者的口服葡萄糖耐量试验(OGTT)中，我们评估了与胰岛素分泌相关的因素。材料和方法：测定17例日本 受试者口服葡萄糖耐量试验期间血浆GIP和GLP-1水平，并用单因素方差分析和多元回归分析评价影响GIP和GLP-1分泌的因素。结果： -GIP分泌量与体重指数(P <； 0.0 5)、C肽(P <； 0.0 5)和胰升糖素曲线下面积(AUC <； 0.0 1)呈正相关，而GLP-1分泌量(AUC-GLP-1)与血糖AUC呈负相关(P <； 0.0 5)。胰岛素分泌指数与GIP分泌的相关性最强(P <； 0.05)；稳态模型评估β细胞是胰岛素分泌和胰岛素敏感性的四个指标中相关性最强的因素(P <； 0.05)。结论：日本受试者 和GLP-1的分泌可能与多种不同的因素有关。(《糖尿病投资》，DOI：10.1111/j.2040-1124.2010.00078.x，2011年)
Aims/Introduction: Gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are major incretins that potentiate insulin secretion from pancreatic β‐cells. The factors responsible for incretin secretion have been reported in Caucasian subjects, but have not been thoroughly evaluated in Japanese subjects. We evaluated the factors associated with incretin secretion during oral glucose tolerance test (OGTT) in Japanese subjects with normal glucose tolerance (NGT). Materials and Methods: We measured plasma GIP and GLP‐1 levels during OGTT in 17 Japanese NGT subjects and evaluated the factors associated with GIP and GLP‐1 secretion using simple and multiple regression analyses. Results: GIP secretion (AUC‐GIP) was positively associated with body mass index (P < 0.05), and area under the curve (AUC) of C‐peptide (P < 0.05) and glucagon (P < 0.01), whereas GLP‐1 secretion (AUC‐GLP‐1) was negatively associated with AUC of plasma glucose (P < 0.05). The insulinogenic index was most strongly associated with GIP secretion (P < 0.05); homeostasis model assessment β‐cell was the most the strongly associated factor in GLP‐1 secretion (P < 0.05) among the four indices of insulin secretion and insulin sensitivity. Conclusions: Several distinct factors might be associated with GIP and GLP‐1 secretion during OGTT in Japanese subjects. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00078.x, 2011)
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DOI：
10.1016/j.bbrc.2010.01.134
发表时间：
2010-03-12
影响因子：
3.1
作者：
Kozawa, Junji;Okita, Kohei;Shimomura, Iichiro
通讯作者：
Shimomura, Iichiro
影响因子：
8.2
作者：
NAUCK, M;STOCKMANN, F;CREUTZFELDT, W
通讯作者：
CREUTZFELDT, W
影响因子：
158.5
作者：
HAFFNER, SM;STERN, MP;PATTERSON, JK
通讯作者：
PATTERSON, JK
影响因子：
7.7
作者：
FLATT, PR;BAILEY, CJ;MARKS, V
通讯作者：
MARKS, V
DOI：
10.1152/ajpendo.00358.2007
发表时间：
2008-01-01
影响因子：
5.1
作者：
Harada, Norio;Yamada, Yuichiro;Inagaki, Nobuya
通讯作者：
Inagaki, Nobuya