Beyond the margins: real-time detection of cancer using targeted fluorophores.
Beyond the margins: real-time detection of cancer using targeted fluorophores.
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DOI：
10.1038/nrclinonc.2016.212
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Weichert JP
中科院分区：
文献类型：
--
作者：
Zhang RR;Schroeder AB;Grudzinski JJ;Rosenthal EL;Warram JM;Pinchuk AN;Eliceiri KW;Kuo JS;Weichert JP
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging. Specifically, advances in fluorophore chemistry and imaging hardware, and the identification of targetable biomarkers have now positioned intraoperative fluorescence as a highly specific real-time detection modality for surgeons in oncology. In particular, the deeper tissue penetration and limited autofluorescence of near-infrared (NIR) fluorescence imaging improves the translational potential of this modality over visible-light fluorescence imaging. Rapid developments in fluorophores with improved characteristics, detection instrumentation, and targeting strategies led to the clinical testing in the early 2010s of the first targeted NIR fluorophores for intraoperative cancer detection. The foundations for the advances that underline this technology continue to be nurtured by the multidisciplinary collaboration of chemists, biologists, engineers, and clinicians. In this Review, we highlight the latest developments in NIR fluorophores, cancer-targeting strategies, and detection instrumentation for intraoperative cancer detection, and consider the unique challenges associated with their effective application in clinical settings.
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影响因子：
--
作者：
Boogerd LS;Boonstra MC;Beck AJ;Charehbili A;Hoogstins CE;Prevoo HA;Singhal S;Low PS;van de Velde CJ;Vahrmeijer AL
通讯作者：
Vahrmeijer AL
影响因子：
11.5
作者：
Barrett, Tristan;Koyama, Yoshinori;Kobayashi, Hisataka
通讯作者：
Kobayashi, Hisataka
DOI：
10.1001/jamaoto.2015.3617
发表时间：
2016-04
期刊：
JAMA otolaryngology-- head & neck surgery
影响因子：
--
作者：
Baik FM;Hansen S;Knoblaugh SE;Sahetya D;Mitchell RM;Xu C;Olson JM;Parrish-Novak J;Méndez E
通讯作者：
Méndez E
用于 NIR-II 成像的小分子染料
影响因子：
41.2
作者：
Antaris, Alexander L.;Chen, Hao;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
6.6
作者：
Bander, NH;Trabulsi, EJ;Goldsmith, SJ
通讯作者：
Goldsmith, SJ