A subpopulation of nociceptors specifically linked to itch.
A subpopulation of nociceptors specifically linked to itch.
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DOI：
10.1038/nn.3289
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发表时间：
2013-02
影响因子：
25
通讯作者：
Dong, Xinzhong
中科院分区：
文献类型：
--
作者：
Han, Liang;Ma, Chao;Liu, Qin;Weng, Hao-Jui;Cui, Yiyuan;Tang, Zongxiang;Kim, Yushin;Nie, Hong;Qu, Lintao;Patel, Kush N.;Li, Zhe;McNeil, Benjamin;He, Shaoqiu;Guan, Yun;Xiao, Bo;LaMotte, Robert H.;Dong, Xinzhong
几十年来，人们一直在寻找瘙痒特异性神经元。这种神经元的存在最近受到怀疑，因为观察到瘙痒介导神经元也对疼痛刺激做出反应。在这里，我们遗传标记和操纵背根神经节（DRG）中的MrgprA3+神经元，发现它们只支配皮肤的表皮，并对多种促炎原作出反应。MrgprA3+神经元的消融导致由多种致敏剂诱发的抓挠显著减少，并且在慢性瘙痒条件下自发发生，而疼痛敏感性保持完整。重要的是，TRPV1只在MrgprA3+神经元中表达的小鼠对辣椒素的反应仅表现出瘙痒而不是疼痛行为。虽然MrgprA3+神经元对伤害性热敏感，但伤害性热激活这些神经元中的TRPV1并不改变疼痛行为。这些数据表明，MrgprA3定义了一个特定的DRG神经元介导瘙痒的亚群。我们的研究为研究瘙痒和开发抗瘙痒疗法开辟了新的途径。
Itch-specific neurons have been sought for decades. The existence of such neurons is in doubt recently due to the observation that itch-mediating neurons also respond to painful stimuli. Here, we genetically labeled and manipulated MrgprA3+ neurons in dorsal root ganglion (DRG) and found that they exclusively innervate the epidermis of the skin and respond to multiple pruritogens. Ablation of MrgprA3+ neurons led to significant reductions in scratching evoked by multiple pruritogens and occurring spontaneously under chronic itch conditions whereas pain sensitivity remained intact. Importantly, mice with TRPV1 exclusively expressed in MrgprA3+ neurons exhibited only itch- and not pain behavior in response to capsaicin. Although MrgprA3+ neurons are sensitive to noxious heat, activation of TRPV1 in these neurons by noxious heat did not alter pain behavior. These data suggest that MrgprA3 defines a specific subpopulation of DRG neurons mediating itch. Our study opens new avenues for studying itch and developing anti-pruritic therapies.
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DOI：
10.3758/bf03205007
发表时间：
1990-07-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
GREEN, BG
通讯作者：
GREEN, BG
DOI：
10.1523/jneurosci.3509-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu Q;Sikand P;Ma C;Tang Z;Han L;Li Z;Sun S;LaMotte RH;Dong X
通讯作者：
Dong X
影响因子：
48
作者：
Buch, T;Heppner, FL;Waisman, A
通讯作者：
Waisman, A
影响因子：
5.3
作者：
Barth, AL;Gerkin, RC;Dean, KL
通讯作者：
Dean, KL
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H