T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses.
T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses.
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DOI：
10.3389/fimmu.2021.679909
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发表时间：
2021
影响因子：
7.3
通讯作者：
Craft J
中科院分区：
文献类型：
--
作者：
Lu Y;Craft J
滤泡调节性T细胞或Tfr细胞是可辨别的调节性T（Treg）细胞群，其在免疫攻击时迁移到B细胞滤泡和生发中心（GC）。这些细胞表达转录因子Bcl6，即T滤泡辅助细胞发育和分化所需的主调节因子，并且是一组先前描述的Treg细胞，其使用T辅助细胞相关转录因子使其调节功能适应不同的环境以维持免疫稳态。虽然Tfr细胞控制B细胞自身反应性是共识，但尚不清楚它们是否调节生产性抗原特异性GC反应。因此，了解Tfr细胞在维持B细胞耐受性同时优化生产性体液免疫的调节平衡对于疫苗设计策略至关重要。为此，我们讨论了最近的证据表明，Tfr细胞促进体液免疫和病毒感染后的记忆，符合公认的作用，调节性T细胞在维持稳态与促进生产性免疫，同时减轻这是潜在的病理。我们还提出了Tfr细胞调节抗原特异性B细胞应答的模型。
T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg) cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge. These cells express the transcription factor Bcl6, the master regulator required for development and differentiation of T follicular helper cells, and are among a group of previously described Treg cells that use T helper cell–associated transcription factors to adapt their regulatory function to diverse milieus for maintenance of immune homeostasis. While there is consensus that Tfr cells control B-cell autoreactivity, it has been unclear whether they regulate productive, antigen-specific GC responses. Accordingly, understanding the regulatory balancing that Tfr cells play in maintenance of B-cell tolerance while optimizing productive humoral immunity is crucial for vaccine-design strategies. To this end, we discuss recent evidence that Tfr cells promote humoral immunity and memory following viral infections, fitting with the accepted role of Treg cells in maintaining homeostasis with promotion of productive immunity, while mitigating that which is potentially pathological. We also propose models in which Tfr cells regulate antigen-specific B cell responses.
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影响因子：
30.5
作者：
Clement, Rachel L.;Daccache, Joe;Sage, Peter T.
通讯作者：
Sage, Peter T.
影响因子：
24.8
作者：
Laidlaw BJ;Lu Y;Amezquita RA;Weinstein JS;Vander Heiden JA;Gupta NT;Kleinstein SH;Kaech SM;Craft J
通讯作者：
Craft J
影响因子：
24.1
作者：
Gu, Peng;Gao, Julia Fang;Zhang, Li
通讯作者：
Zhang, Li
影响因子：
3.7
作者：
Dal Secco V;Soldani C;Debrat C;Asperti-Boursin F;Donnadieu E;Viola A;Sarukhan A
通讯作者：
Sarukhan A
DOI：
10.1084/jem.20111174
发表时间：
2012-02-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Johnston RJ;Choi YS;Diamond JA;Yang JA;Crotty S
通讯作者：
Crotty S