Effects of sleep restriction on glucose control and insulin secretion during diet-induced weight loss.
Effects of sleep restriction on glucose control and insulin secretion during diet-induced weight loss.
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DOI：
10.1038/oby.2012.97
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发表时间：
2012-07
期刊：
影响因子：
6.9
通讯作者：
Penev, Plamen D.
中科院分区：
文献类型：
--
作者：
Nedeltcheva, Arlet V.;Imperial, Jacqueline G.;Penev, Plamen D.
睡眠不足与葡萄糖耐量、胰岛素分泌和胰岛素作用的变化有关。尽管减肥饮食被广泛用于降低代谢风险，但睡眠不足对超重节食者血糖调节的影响尚不清楚。为了研究反复睡眠限制对饮食诱导减肥期间24小时血糖控制的影响，10名超重和肥胖成人（3F/7M；平均[SD]年龄41 b[5]岁；BMI 27.4 [2.0] kg/m2）完成了两项为期14天的低热量饮食和8.5或5.5小时夜间睡眠时间的治疗，随机顺序间隔7[3]个月。每次治疗后收集口服和静脉葡萄糖耐量试验（IVGTT）数据、空腹血脂和游离脂肪酸（FFA）、24小时血糖、胰岛素、c肽和抗调节激素测量。在每次治疗期间，参与者的体重减轻相当（1.0 [0.3]BMI单位）。就寝时间限制使睡眠时间减少了131分钟/天。反复睡眠减少会降低24小时血清胰岛素浓度（即增强24小时胰岛素经济性），而口服葡萄糖耐量和24小时血糖控制没有变化。这伴随着空腹血糖的下降，空腹FFA的增加（通常在葡萄糖摄入后被抑制），总胆固醇和低密度脂蛋白胆固醇浓度的降低。在IVGTT期间，与睡眠不足相关的反调节激素分泌的变化限制了该试验在本研究中的实用性。综上所述，睡眠限制在不影响均衡低热量饮食的超重个体的葡萄糖稳态的情况下增强了24小时胰岛素经济性。睡眠限制节食者的空腹血糖、胰岛素、脂质和游离脂肪酸浓度的变化与人类代谢适应碳水化合物减少的模式相似。
Insufficient sleep is associated with changes in glucose tolerance, insulin secretion, and insulin action. Despite widespread use of weight-loss diets for metabolic risk reduction, the effects of insufficient sleep on glucose regulation in overweight dieters are not known. To examine the consequences of recurrent sleep restriction on 24-hour blood glucose control during diet-induced weight loss, 10 overweight and obese adults (3F/7M; mean [SD] age 41 [5] y; BMI 27.4 [2.0] kg/m2) completed two 14-day treatments with hypocaloric diet and 8.5 or 5.5-h nighttime sleep opportunity in random order 7 [3] months apart. Oral and intravenous glucose tolerance test (IVGTT) data, fasting lipids and free-fatty acids (FFA), and 24-hour blood glucose, insulin, C-peptide, and counter-regulatory hormone measurements were collected after each treatment. Participants had comparable weight loss (1.0 [0.3] BMI units) during each treatment. Bedtime restriction reduced sleep by 131 [30] min/day. Recurrent sleep curtailment decreased 24-hour serum insulin concentrations (i.e. enhanced 24-hour insulin economy) without changes in oral glucose tolerance and 24-hour glucose control. This was accompanied by a decline in fasting blood glucose, increased fasting FFA which suppressed normally following glucose ingestion, and lower total and LDL cholesterol concentrations. Sleep-loss-related changes in counter-regulatory hormone secretion during the IVGTT limited the utility of the test in this study. In conclusion, sleep restriction enhanced 24-hour insulin economy without compromising glucose homeostasis in overweight individuals placed on a balanced hypocaloric diet. The changes in fasting blood glucose, insulin, lipid and FFA concentrations in sleep-restricted dieters resembled the pattern of human metabolic adaptation to reduced carbohydrate availability.
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影响因子：
7.7
作者：
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通讯作者：
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DOI：
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